Macrophages in Transplantation: A Matter of Plasticity, Polarization, and Diversity.
Macrophages in Transplantation: A Matter of Plasticity, Polarization, and Diversity.
复制标题
移植中的巨噬细胞：可塑性，极化和多样性问题。
DOI：
10.1097/tp.0000000000003804
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发表时间：
2022-02-01
期刊：
影响因子：
6.2
通讯作者：
Panzer SE
中科院分区：
文献类型：
--
作者：
Panzer SE
由于基础科学的最新进展，巨噬细胞已经出现在免疫学和移植研究的前沿。新的发现阐明了以前未发现的巨噬细胞群体，扩展了传统的巨噬细胞表型，并彻底改变了巨噬细胞的个体发育。这些进展对移植免疫学领域具有重大意义。众所周知，巨噬细胞会引发适应性免疫反应，使T细胞介导的排斥反应和抗体介导的排斥反应持续存在，并促进同种异体移植物纤维化。在这篇综述中，巨噬细胞表型及其在实体器官移植中的作用将重点讨论肾移植。此外，将考虑操纵巨噬细胞表型作为基于细胞的治疗的前景。先天免疫和巨噬细胞是同种异体移植物损伤的重要参与者，也是改善移植结果的有希望的靶点。
Macrophages have emerged at the forefront of research in immunology and transplantation due to recent advances in basic science. New findings have illuminated macrophage populations not identified previously, expanded upon traditional macrophage phenotypes, and overhauled macrophage ontogeny. These advances have major implications for the field of transplant immunology. Macrophages are known to prime adaptive immune responses, perpetuate T cell-mediated rejection and antibody-mediated rejection, and promote allograft fibrosis. In this review, macrophage phenotypes and their role in allograft injury of solid organ transplants will be discussed with an emphasis on kidney transplantation. Additionally, consideration will be given to the prospect of manipulating macrophage phenotypes as cell-based therapy. Innate immunity and macrophages represent important players in allograft injury and a promising target to improve transplant outcomes.