A Case of Delayed Radiation Myelopathy of the Thoracic Vertebrae Following Low Dose Radiation Therapy for Metastatic Renal Cell Carcinoma.
A Case of Delayed Radiation Myelopathy of the Thoracic Vertebrae Following Low Dose Radiation Therapy for Metastatic Renal Cell Carcinoma.
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DOI：
10.1016/j.eucr.2017.01.005
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发表时间：
2017-02
影响因子：
0.5
通讯作者：
Yasui T
中科院分区：
文献类型：
--
作者：
Nozaki S;Naiki T;Hamamoto S;Ando R;Iida K;Kawai N;Mizuno K;Okada A;Umemoto Y;Yasui T
迟发性放射性脊髓病（DRM）是一种迅速导致残疾的罕见疾病，据报道中位潜伏期约为2年（从6个月到几年）。在本报告中，我们描述了一位61岁的女性，在接受3gy / 39gy的姑息性放射治疗22个月后，她出现了两腿快速进行性麻木和无力。她被诊断为胸椎DRM，并接受了皮质类固醇、肝素和高压氧治疗。然而，这些药物没有效果，3个月后腿部完全瘫痪。
Delayed radiation myelopathy (DRM) is a rare disorder that rapidly leads to disabilities, and the median incubation period was reported to be about 2 years (from 6 months to a few years). In this report, we describe a 61-year-old woman who presented with rapid progressive numbness and weakness in both legs 22 months after palliative radiation therapy with 39 Gy in 3 Gy fractions. She was diagnosed with DRM of the thoracic vertebrae and was treated sequentially with corticosteroids, heparin, and hyperbaric oxygen therapy. However, they were not effective, and complete paralysis of the legs occurred in 3 months.