Peroxynitrite versus nitric oxide in early diabetes (Retracted Article)
Peroxynitrite versus nitric oxide in early diabetes (Retracted Article)
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DOI：
10.1016/s0895-7061(03)00976-2
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发表时间：
2003-09-01
影响因子：
3.2
通讯作者：
Baylis, C
中科院分区：
文献类型：
--
作者：
Hoeldtke, RD;Bryner, KD;Baylis, C
背景：过氧亚硝酸盐是一氧化氮（NO）被超氧阴离子失活过程中形成的有毒化合物。这种 NO 代谢途径的生理学意义从未在体内得到记录。由于过氧亚硝酸盐提供了 NO 失活的途径，因此我们推测过氧亚硝酸盐与生理参数的相关性与 NO 的相关性相反，NO 是一种血管舒张剂并抑制催汗功能。我们通过将过氧亚硝酸盐与血压 (BP) 和促汗反应的相关性与 NO 的相关性进行比较，评估了过氧亚硝酸盐的重要性。方法：37 名 I 型糖尿病患者参加了氧化应激的纵向研究。从亚硝酸盐和硝酸盐（统称为 NOx）中评估一氧化氮，从蛋白质的硝基酪氨酸 (nTy) 含量评估过氧化亚硝酸盐。结果：对照受试者中的 nTy 为 13.3 +/- 2.0 mumol/L，26.8 +/- 4.4 mumol/L、26.1+/- 4.3 mumol/L 和 32.7 +/- 4.3 mumol/L糖尿病患者中（P
Background: Peroxynitrite is a toxic compound formed during the inactivation of nitric oxide (NO) by the superoxide anion. The physiologic significance of this pathway of NO metabolism has never been documented in vivo. Because peroxynitrite provides a pathway for the inactivation of NO we postulated that peroxyrtitrite's correlation with physiologic parameters would be the opposite of those associated with NO, which is a vasodilator and suppresses sudomotor function. We assessed the significance of peroxynitrite by comparing its associations with blood pressure (BP) and sudomotor responses with those of NO.Methods: Thirty-seven patients with type I diabetes enrolled in a longitudinal study of oxidative stress. Nitric C oxide was assessed from nitrite and nitrate (collectively NOx) and peroxynitrite was assessed from the nitrotyrosine (nTy) content of protein.Results: nTy was 13.3 +/- 2.0 mumol/L in the control subjects and 26.8 +/- 4.4 mumol/L, 26.1+/- 4.3 mumol/L, and 32.7 +/- 4.3 mumol/L in the diabetic patients (P