Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy
Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy
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DOI：
10.1016/j.biopsych.2003.09.010
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发表时间：
2004-03-01
影响因子：
10.6
通讯作者：
Cullum, CM
中科院分区：
文献类型：
--
作者：
Brown, ES;Woolston, DJ;Cullum, CM
背景：据报道，重度抑郁症患者的海马体积减少、陈述性记忆缺陷和皮质醇升高，但缺乏将皮质醇升高与海马萎缩联系起来的数据。接受处方皮质类固醇治疗的患者提供了一个机会来检查皮质类固醇对人类海马体积、生物化学和记忆力的影响。方法：使用磁共振成像和质子磁共振波谱、雷伊听觉语言学习测试、斯特鲁普色词测试和其他神经认知测量、汉密尔顿抑郁量表、青少年抑郁症评定量表对 17 名长期接受处方皮质类固醇治疗的患者和 15 名年龄、性别、种族、教育、身高和病史相似的对照进行评估。结果：与对照组相比，接受皮质类固醇治疗的患者海马体积较小，N-乙酰天冬氨酸比率较低，雷伊听觉言语学习测试和斯特鲁普色词测试得分较低，汉密尔顿抑郁评定量表和简要精神病评定量表得分较高。结论：接受长期皮质类固醇治疗的患者海马体积较小，N-乙酰天冬氨酸比率较低与对照组相比，这些发现支持了这样的观点：皮质类固醇暴露似乎与人类海马体积和功能的变化有关。
Background: Hippocampal volume reduction, declarative memory deficits, and cortisol elevations are reported in persons with major depressive disorder, however, data linking cortisol elevations with hippocampal atrophy are lacking. Prescription corticosteroid-treated patients offer an opportunity to examine corticosteroid effects on hippocampal volume and biochemistry and memory in humans.Methods: Seventeen patients on long-term prescription corticosteroid therapy and 15 controls of similar age, gender, ethnicity, education, height, and medical history were assessed with magnetic resonance imaging and proton magnetic resonance spectroscopy, the Rey Auditory Verbal Learning Test, Stroop Color Word Test and other neurocognitive measures, the Hamilton Rating Scale for Depression, Young Mania Rating Scale, and Brief Psychiatric Rating Scale.Results: Compared with controls, corticosteroid-treated patients had smaller hippocampal volumes and lower N-acetyl aspartate ratios, lower scores on the Rey Auditory Verbal Learning Test and Stroop Color Word Test, and higher Hamilton Rating Scale for Depression and Brief Psychiatric Rating Scale scores.Conclusions: Patients receiving chronic corticosteroid therapy have smaller hippocampal volumes, lower N-acetyl aspartate ratios, and declarative memory deficits compared with controls, These findings support the idea that corticosteroid exposure appears to be associated with changes in hippocampal volume and functioning in humans.