Factors predicting for response and survival in adults with advanced non-Hodgkin's lymphoma.
Factors predicting for response and survival in adults with advanced non-Hodgkin's lymphoma.
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预测晚期非霍奇金淋巴瘤成人的反应和生存的因素。
DOI：
10.1001/archinte.1978.03630270051019
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发表时间：
1978
影响因子：
--
通讯作者：
V. Rodriguez
中科院分区：
文献类型：
--
作者：
F. Cabanillas;J. S. Burke;T. Smith;T. Moon;J. Butler;V. Rodriguez
了解疾病的预后因素有助于规划和分析临床试验。本研究旨在探讨接受环磷酰胺、硫酸长春新碱和强的松联合治疗的III期和IV期非霍奇金淋巴瘤患者的反应和生存特征。分别考虑每个特征，采用逐步回归分析，肿瘤体积、治疗前、性别和治疗前淋巴细胞计数被选为四个最重要的预后变量。肿瘤结构(弥漫性或结节型)和细胞类型、血红蛋白水平和症状虽然在预测疗效方面不重要，但在预测生存率方面被发现是重要的。血红蛋白水平在预测反应方面只有微不足道的重要性。未发现的重要因素有年龄、分期、症状、细胞类型、结节、骨髓受累、既往广泛放射治疗和骨骼受累。建立了可用于预测应答率的Logistic回归方程。
Knowledge of the prognostic factors that characterize a disease can assist in planning and analyzing clinical trials. The present study was conducted to determine the characteristics related to response and survival in patients with stage III and IV non-Hodgkin's lymphoma who were treated with combinations of cyclophosphamide, vincristine sulfate, and prednisone. Considering each characteristic individually and using stepwise regression analysis, tumor bulkiness, prior therapy, sex, and pretreatment lymphocyte count were selected as the four most important prognostic variables. Tumor architecture (diffuse or nodular pattern) and cell type, hemoglobin level, and symptoms although not important in predicting response were found to be important in predicting survival. The hemoglobin level had only marginal importance in predicting response. Factors found not be important were age, stage, symptoms, cell type, nodularity, marrow involvement, prior extensive radiotherapy, and bone involvement. A logistic regression equation has been derived that can be used to predict response rate.