Droplet fusion by alternating current (AC) field electrocoalescence in microchannels
Droplet fusion by alternating current (AC) field electrocoalescence in microchannels
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DOI：
10.1002/elps.200500109
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发表时间：
2005-10-01
期刊：
影响因子：
2.9
通讯作者：
Viovy, JL
中科院分区：
文献类型：
--
作者：
Chabert, M;Dorfman, KD;Viovy, JL
我们提出了一种用于微流控液滴在不相容溶剂中的电聚并的系统，其中未变形的液滴直径与通道直径相当。电极不与载液或液滴直接接触，从而将不同聚结事件之间的交叉污染风险降至最低。给出了静态和流动氟碳流中缓冲水滴聚结的结果，并演示了飞行中的聚结。这里介绍的基于毛细管的系统很容易进一步小型化，适用于任何液滴的电导率远远大于含有液滴的水流的电导率的芯片实验室应用，并应有助于液滴微反应器在生物分析中的进一步应用。
We present a system for the electrocoalescence of microfluidic droplets immersed in an immiscible solvent, where the undeformed droplet diameters are comparable to the channel diameter. The electrodes are not in direct contact with the carrier liquid or the droplets, thereby minimizing the risk of cross-contamination between different coalescence events. Results are presented for the coalescence of buffered aqueous droplets in both quiescent and flowing fluorocarbon streams, and on-flight coalescence is demonstrated. The capillary-based system presented here is readily amenable to further miniaturization to any lab-on-a-chip application where the conductivity of the droplets is much greater than the conductivity of the stream containing them, and should aid in the further application of droplet microreactors to biological analyses.