MULTIPLE OUTPUT CHANNELS IN THE BASAL GANGLIA
MULTIPLE OUTPUT CHANNELS IN THE BASAL GANGLIA
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DOI：
10.1126/science.7679223
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发表时间：
1993-02-05
期刊：
影响因子：
56.9
通讯作者：
STRICK, PL
中科院分区：
文献类型：
--
作者：
HOOVER, JE;STRICK, PL
连接基底神经节和大脑皮层的神经回路对于随意运动的产生和控制至关重要。使用 1 型单纯疱疹病毒逆行跨神经元转运来检查宿雾猴基底神经节输出核、苍白球内段 (GPi) 和三个皮质区域（初级运动皮质、辅助运动区域和腹侧前运动区域）之间的连接组织。将病毒注射到每个皮质区域后，对 GPi 的空间分离区域进行标记。 GPi 投射到多个皮质运动区域，并且这种苍白球输出被组织成离散的通道。该信息为检查基底神经节在骨骼运动控制中的功能提供了一个新的解剖框架。
The neural circuits that link the basal ganglia with the cerebral cortex are critically involved in the generation and control of voluntary movement. Retrograde transneuronal transport of herpes simplex virus type 1 was used to examine the organization of connections in the cebus monkey between an output nucleus of the basal ganglia, the internal segment of the globus pallidus (GPi), and three cortical areas: the primary motor cortex, the supplementary motor area, and the ventral premotor area. Spatially separate regions of the GPi were labeled after virus injections into each cortical area. The GPi projects to multiple cortical motor areas, and this pallidal output is organized into discrete channels. This information provides a new anatomical framework for examining the function of the basal ganglia in skeletomotor control.