High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults
High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults
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DOI：
10.2337/dc19-0100
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发表时间：
2019-11-01
期刊：
影响因子：
16.2
通讯作者：
Wang, Weiqing
中科院分区：
文献类型：
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作者：
Lu, Jieli;Lam, Sin Man;Wang, Weiqing
目的对中国汉族人2型糖尿病(T2 DM)发病前的血清脂代谢异常进行全面评估。我们评估了T2 DM前血脂协同调节的变化，并在糖调节正常(NGR)的个体中确定了T2 DM的新的血脂预测指标。研究设计与方法在DISCOVERY研究中，我们从3821名患有NGR的中国成年人组成的前瞻性队列中检测了667名糖尿病患者和倾向得分匹配的对照组受试者(n=200)的基线血脂。在验证研究中，我们测试了来自中国五个地理区域的14,651名患有NGR的混合验证队列中的250名糖尿病患者和匹配的对照组受试者(n=724)的血脂。差分相关网络分析揭示了糖尿病之前的受扰的血脂协同调节。此外，还评估了独立于血清甘油三酯和负荷后2小时血糖的血脂指标的预测价值。错误发现率水平的结果
OBJECTIVE Comprehensive assessment of serum lipidomic aberrations before type 2 diabetes mellitus (T2DM) onset has remained lacking in Han Chinese. We evaluated changes in lipid coregulation antecedent to T2DM and identified novel lipid predictors for T2DM in individuals with normal glucose regulation (NGR). RESEARCH DESIGN AND METHODS In the discovery study, we tested 667 baseline serum lipids in subjects with incident diabetes and propensity score-matched control subjects (n = 200) from a prospective cohort comprising 3,821 Chinese adults with NGR. In the validation study, we tested 250 lipids in subjects with incident diabetes and matched control subjects (n = 724) from a pooled validation cohort of 14,651 individuals with NGR covering five geographical regions across China. Differential correlation network analyses revealed perturbed lipid coregulation antecedent to diabetes. The predictive value of a serum lipid panel independent of serum triglycerides and 2-h postload glucose was also evaluated. RESULTS At the level of false-discovery rate