Neuronal organization of the rat inferior colliculus participating in four major auditory pathways
Neuronal organization of the rat inferior colliculus participating in four major auditory pathways
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DOI：
10.1016/j.heares.2006.04.004
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发表时间：
2006-08-01
期刊：
影响因子：
2.8
通讯作者：
Harada, Shinichi
中科院分区：
文献类型：
--
作者：
Okoyama, Shigeo;Ohbayashi, Masao;Harada, Shinichi
下丘中央核(CNIC)含有不同类型的神经元，是向内侧膝状体(MGB)的上行投射、向对侧IC的连合投射、向耳蜗核(CN)的直接下行投射和通过上橄榄复合体(SOC)向CN的间接投射的来源。使用逆行追踪技术，我们检测了CNIC中识别的每种类型的神经元参与了上述四种投射通路的类型和百分比。我们还研究了单个CNIC神经元是否向NIGB、对侧IC、CN和SO3发出侧支。在本研究中，我们证明了参与这四种投射的神经元在形态上可以分为两种类型，胞体大小不同。在四种投射通路中，每种类型神经元所占的百分比不同。使用双标记技术，我们发现很少的双标记神经元，表明侧支投射到同侧MGB和对侧IC。在其他靶点组合之间的侧支投射中没有双标记神经元。因此，我们得出结论，对这些靶点的上升投射、连合投射和下降投射分别来自不同的神经元群体。(C)2006爱思唯尔B.V.保留所有权利。
The central nucleus of the inferior colliculus (CNIC) contains different types of neurons and is a source of ascending projection to the medial geniculate body (MGB), commissural projection to the contralateral IC, direct descending projection to the cochlea nucleus (CN) and indirect projection to the CN via the superior olivary complex (SOC). Using a retrograde tracing technique, we examined what kind of neurons and what percentage of neurons of each type recognized in the CNIC participated in the above-mentioned four projection pathways. We also examined whether the individual CNIC neurons send the collateral to the NIGB, the contralateral IC, the CN and the soc.In the present study, we demonstrated that the neurons participating in the four projections could be morphologically classified into two types of neurons with soma size variation. The percentages of neurons of each type differed among the four projection pathways. Using a double-labeling technique, we found very few double-labeled neurons, indicating the collateral projections to the ipsilateral MGB and the contralateral IC. There were no double-labeled neurons in the collateral projections between the other combinations of targets. Therefore, we conclude that the ascending projection, the commissural projection and the descending projection to these targets arise from separate populations of neurons. (c) 2006 Elsevier B.V. All rights reserved.