The importance of cochlear processing for the formation of auditory brainstem and frequency following responses
The importance of cochlear processing for the formation of auditory brainstem and frequency following responses
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DOI：
10.1121/1.1534833
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发表时间：
2003-02-01
影响因子：
2.4
通讯作者：
Dau, T
中科院分区：
文献类型：
--
作者：
Dau, T
提出了一种产生听觉脑干反应（ABR）和频率跟随反应（FFR）的模型。该模型基于Goldstein和Kiang [J. Acoust.美国社会30，107-114（1958）]，在远程电极处记录的诱发电位理论上可以通过基本单位波形（单一响应）与对应单位的瞬时放电速率函数的卷积来给出。在本研究中，海因茨等人[ARLO 2（3），91-96（2001）]最近开发的非线性计算神经-神经模型用于计算在0.1和10 kHz的频率范围内纤维i的瞬时放电速率r（i）（t）。将频率上的总活动与单一响应进行卷积，该单一响应被假设为反映来自听觉脑干内不同细胞群的贡献，在头皮上的给定电极对处记录。预测的潜在模式与实验数据进行比较，为一些刺激和水平条件。如Dau等人[J. Acoust.美国社会107，1530-1540（2000）]，考虑了包括啁啾以及音调和缓慢变化的音调扫描的长持续时间刺激。结果表明，考虑基底膜行波和神经加工对ABR和FFR形成的影响的重要性。具体而言，结果支持以下假设：低频音调的FFR代表主要源自更多基底部位的中频和高频单位的同步活动，而不是调谐到信号频率附近频率的单位。(C)2003年，美国声学学会。
A model for the generation of auditory brainstem responses (ABR) and frequency following responses (FFRs) is presented. The model is based on the concept introduced by Goldstein and Kiang [J. Acoust. Soc. Am. 30, 107-114 (1958)] that evoked potentials recorded at remote electrodes can theoretically be given by convolution of an elementary unit waveform (unitary response) with the instantaneous discharge rate function for the corresponding unit. In the present study, the nonlinear computational auditory-nerve model recently developed by Heinz et al. [ARLO 2(3), 91-96 (2001)] was used to calculate the instantaneous discharge rate r(i)(t) for fibers i in the frequency range from 0.1 and 10 kHz. The summed activity across frequency was convolved with a unitary response which is assumed to reflect contributions from different cell populations within the auditory brainstem, recorded at a given pair of electrodes on the scalp. Predicted potential patterns are compared with experimental data for a number of stimulus and level conditions. Clicks, chirps as defined in Dau et al. [J. Acoust. Soc. Am. 107, 1530-1540 (2000)], long-duration stimuli comprising the chirp, as well as tones and slowly varying tonal sweeps were considered. The results demonstrate the importance of considering the effects of the basilar-membrane traveling wave and auditory-nerve processing for the formation of ABR and FFR. Specifically, the results support the hypothesis that the FFR to low-frequency tones represents synchronized activity mainly stemming from mid- and high-frequency units at more basal sites, and not from units tuned to frequencies around the signal frequency. (C) 2003 Acoustical Society of America.