Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19.
Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19.
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DOI：
10.3389/fcvm.2020.582399
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发表时间：
2020
影响因子：
3.6
通讯作者：
Alsheikh-Ali A
中科院分区：
文献类型：
--
作者：
Hachim MY;Al Heialy S;Senok A;Hamid Q;Alsheikh-Ali A
背景：2019 年冠状病毒病（COVID-19）是由新型冠状病毒 SARS-CoV-2 引起的病毒性呼吸道疾病。既存心脏病的存在与 COVID-19 患者出现严重临床病程和死亡率的可能性增加有关。此外，目前的证据表明，即使在没有已知的心脏危险因素的情况下，大量 COVID-19 患者也表现出心血管受累。因此，有必要了解解释 COVID-19 心血管受累的根本机制和遗传倾向。目标：对公开数据集进行计算机分析，以破译分子基础、潜在途径以及内皮在 COVID-19 心脏和血管损伤发病机制中的作用。材料和方法：与健康对照相比，在静脉血栓栓塞“VTE”、急性冠状动脉综合征、心力衰竭和/或心源性休克（与 COVID-19 相关的主要心血管损伤）患者的五个微阵列转录组分析数据集中，鉴定出了内皮细胞和外周免疫细胞共有的一致的显着差异表达基因 (DEG)。在公开的转录组数据集中进一步检查了已识别的基因，以了解不同种族的肺组织以及 SARS-CoV-2 感染与模拟感染的肺组织和心肌细胞中的细胞/组织特异性。结果：我们鉴定了血液和内皮细胞中的 36 个 DEG，这些 DEG 在内皮和血管生物学、细胞应激反应调节以及内皮细胞迁移中发挥着关键作用。其中一些基因在 SARS-CoV-2 感染的肺组织中显着上调。另一方面，一些具有心脏保护功能的基因在SARS-CoV-2感染的心肌细胞中表达下调。结论：总而言之，我们对公开转录组数据集的分析结果确定了与心脏和血管相关损伤相关的共享核心基因及其在 COVID-19 患者心血管损伤遗传易感性中的可能作用。
Background: Coronavirus disease 2019 (COVID-19) is a viral respiratory illness caused by the novel coronavirus SARS-CoV-2. The presence of the pre-existing cardiac disease is associated with an increased likelihood of severe clinical course and mortality in patients with COVID-19. Besides, current evidence indicates that a significant number of patients with COVID-19 also exhibit cardiovascular involvement even in the absence of known cardiac risk factors. Therefore, there is a need to understand the underlying mechanisms and genetic predispositions that explain cardiovascular involvement in COVID-19. Objectives: In silico analysis of publicly available datasets to decipher the molecular basis, potential pathways, and the role of the endothelium in the pathogenesis of cardiac and vascular injuries in COVID-19. Materials and Methods: Consistent significant differentially expressed genes (DEGs) shared by endothelium and peripheral immune cells were identified in five microarray transcriptomic profiling datasets in patients with venous thromboembolism “VTE,” acute coronary syndrome, heart failure and/or cardiogenic shock (main cardiovascular injuries related to COVID-19) compared to healthy controls. The identified genes were further examined in the publicly available transcriptomic dataset for cell/tissue specificity in lung tissue, in different ethnicities and in SARS-CoV-2 infected vs. mock-infected lung tissues and cardiomyocytes. Results: We identified 36 DEGs in blood and endothelium known to play key roles in endothelium and vascular biology, regulation of cellular response to stress as well as endothelial cell migration. Some of these genes were upregulated significantly in SARS-CoV-2 infected lung tissues. On the other hand, some genes with cardioprotective functions were downregulated in SARS-CoV-2 infected cardiomyocytes. Conclusion: In conclusion, our findings from the analysis of publicly available transcriptomic datasets identified shared core genes pertinent to cardiac and vascular-related injuries and their probable role in genetic susceptibility to cardiovascular injury in patients with COVID-19.
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影响因子：
4.6
作者：
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
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影响因子：
7.7
作者：
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通讯作者：
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