Rapid membrane protein topology prediction
Rapid membrane protein topology prediction
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DOI：
10.1093/bioinformatics/btr119
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发表时间：
2011-05-01
期刊：
影响因子：
5.8
通讯作者：
Elofsson, Arne
中科院分区：
文献类型：
--
作者：
Hennerdal, Aron;Elofsson, Arne
最先进的α -螺旋膜蛋白拓扑方法是基于使用从PSI-BLAST或其他来源获得的耗时的多序列比对。在这里，我们研究是否有可能使用基于单序列的拓扑预测方法的一致性来获得与更精确的基于多序列的方法相似的精度。在这里，我们表明topcon -single比这里测试的任何其他拓扑预测方法都要好，但比使用多个序列比对的最佳方法差6%。
State-of-the-art methods for topology of alpha-helical membrane proteins are based on the use of time-consuming multiple sequence alignments obtained from PSI-BLAST or other sources. Here, we examine if it is possible to use the consensus of topology prediction methods that are based on single sequences to obtain a similar accuracy as the more accurate multiple sequence-based methods. Here, we show that TOPCONS-single performs better than any of the other topology prediction methods tested here, but similar to 6% worse than the best method that is utilizing multiple sequence alignments.