Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase
Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase
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DOI：
10.1191/1358863x03vm476oa
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发表时间：
2003-05-01
影响因子：
3.5
通讯作者：
Rajagopalan, S
中科院分区：
文献类型：
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作者：
Duquaine, D;Hirsch, GA;Rajagopalan, S
阿霉素(ADR)是一种常用的化疗药物，被认为是通过产生氧自由基来发挥作用的。我们假设，单次给药会导致内皮型一氧化氮合酶(ENOS)依赖的超氧化物歧化(O-2(环状))和急性内皮功能障碍。单剂ADR(10 mg/kg静脉注射)给兔服用可迅速减弱对乙酰胆碱和钙离子载体的激动剂依赖反应(A23187)。环状节段对ADR的体外暴露
Adriamycin (ADR) is a commonly used chemotherapeutic agent that is believed to exert its effects through the generation of oxygen free radicals. We hypothesized that administration of a single dose of ADR results in endothelial nitric oxide synthase (eNOS)-dependent generation of superoxide (O-2(circle-)) and acute endothelial dysfunction. A single dose of ADR (10 mg/kg i.v.) administered to rabbits resulted in rapid attenuation of agonist-dependent responses to acetylcholine and calcium ionophore (A23187). In vitro exposure of ring segments to ADR for