Parkinson's disease and thyroid dysfunction
Parkinson's disease and thyroid dysfunction
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DOI：
10.1016/j.parkreldis.2004.03.008
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发表时间：
2004-08-01
影响因子：
4.1
通讯作者：
Werneck, LC
中科院分区：
文献类型：
--
作者：
Munhoz, RP;Teive, HAG;Werneck, LC
背景资料：虽然甲状腺功能减退症和帕金森病（PD）之间没有因果关系已被证明到目前为止，两者有共同的表现和共存可能是诊断延迟和混乱的来源。目的：评价帕金森病患者甲状腺功能。Scope.通过临床评估和实验室筛查，对95例PD患者和102例年龄匹配的对照者进行甲状腺功能减退症评估。结果：PD组甲状腺功能低下发生率为13.7%，对照组为10.8%。统计分析未显示显著差异（p = 0.3681）。结论虽然甲状腺功能减退症在我们的PD患者中并不比对照组更普遍，但我们认为，考虑到症状和体征的潜在重叠，应评估症状恶化的患者的甲状腺功能，这些症状恶化不能通过疾病进展或对治疗调整的抵抗来解释;筛查应考虑左旋多巴对血清TSH水平的特殊急性影响。(C)2004爱思唯尔有限公司保留所有权利。
Background: Although no causal linkage between hypothyroidism and Parkinson's disease (PD) has been demonstrated so far, both share common manifestations and coexistence can be a source of diagnostic delay and confusion. Purpose: To assess thyroid function in patients with PD. Scope. Ninety-five PD patients and 102 age-matched controls were assessed for hypothyroidism through clinical evaluation and laboratory screening. Results: In the PD group 13.7% were hypothyroid versus 10.8% in the control group. Statistical analysis did not show a significant difference (p = 0.3681). Conclusion. Although hypothyroidism was not more prevalent in our PD patients in comparison with the control group, we believe that given the potential overlap of symptoms and signs, thyroid function should be assessed in patients showing worsening of symptoms that cannot be explained by disease progression or resistance to therapy adjustment; screening should take into account the particular acute effect of levodopa on serum TSH levels. (C) 2004 Elsevier Ltd. All rights reserved.