CYTOKINE PATTERNS IN THE PATHOGENESIS OF HUMAN LEISHMANIASIS
CYTOKINE PATTERNS IN THE PATHOGENESIS OF HUMAN LEISHMANIASIS
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DOI：
10.1172/jci116341
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发表时间：
1993-04-01
影响因子：
15.9
通讯作者：
MODLIN, RL
中科院分区：
文献类型：
--
作者：
PIRMEZ, C;YAMAMURA, M;MODLIN, RL
宿主对感染的反应似乎受到局部细胞因子产生的特定模式的调节。在小鼠中，对包括利什曼原虫在内的许多病原体的抗性与T（H）1细胞因子谱、IL-2和IFN-γ相关;而对感染的易感性与T（H）2细胞因子、IL-4、IL-5和IL-10的产生相关。为了确定人类利什曼原虫感染的局部免疫反应的细胞因子模式，我们使用聚合酶链反应比较美国皮肤利什曼病活检标本中的细胞因子mRNA。在局部皮肤利什曼病和黑山迟发型超敏反应，1型细胞因子的mRNA，如IL-2，IFN-γ，和α-光毒素是相对占主导地位。在慢性和破坏性粘膜皮肤形式的利什曼病，有1型和2型细胞因子的混合物，与一个惊人的丰富的IL-4 mRNA的病变。这些结果表明，巴西利什曼原虫感染的人的临床过程与特定的局部细胞因子的生产模式。
The host response to infection appears to be regulated by specific patterns of local cytokine production. In the mouse, resistance to many pathogens including Leishmania is associated with a T(H)1 cytokine profile, IL-2 and IFN-gamma; whereas susceptibility to infection is associated with production of T(H)2 cytokines, IL-4, IL-5, and IL-10. To determine the cytokine patterns of the local immune response to Leishmania infection in humans, we used the polymerase chain reaction to compare cytokine mRNAs in biopsy specimens of American cutaneous leishmaniasis. In localized cutaneous leishmaniasis and the Montenegro delayed-type hypersensitivity reaction, type 1 cytokine mRNAs such as IL-2, IFN-gamma, and lymphotoxin were relatively predominant. In the chronic and destructive mucocutaneous form of leishmaniasis, there was a mixture of type 1 and type 2 cytokines, with a striking abundance of IL-4 mRNA in lesions. These results suggest that clinical course of infection with Leishmania braziliensis in man is associated with specific local patterns of cytokine production.