Stereospecific Sulfur-Mediated Cleavage of a Spirocyclobutanone: Synthesis of a Fully Functional Precursor to the CP Compounds.
Stereospecific Sulfur-Mediated Cleavage of a Spirocyclobutanone: Synthesis of a Fully Functional Precursor to the CP Compounds.
复制标题
螺环丁酮的立体特异性硫介导裂解：合成 CP 化合物的全功能前体。
作者：
D. Meng;S. Danishefsky
由Sakurai反应、烯酮环化、硫导向的Baeyer-Villiger反应和串联内酯裂解/异构化组成的反应序列提供了CP化合物的完全官能化的核心。关键步骤是1的甲醇分解，其经由2通向CP前体3。
A reaction sequence made up of a Sakurai reaction, ketene cyclization, sulfur-directed Baeyer-Villiger reaction, and tandem lactone cleavage/isomerization provided the fully functionalized core of the CP compounds. Key steps were the methanolysis of 1, which leads via 2 to the CP precursor 3.