COLLATERALIZATION OF THE AMYGDALOID PROJECTIONS OF THE RAT PRELIMBIC AND INFRALIMBIC CORTICES
COLLATERALIZATION OF THE AMYGDALOID PROJECTIONS OF THE RAT PRELIMBIC AND INFRALIMBIC CORTICES
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DOI：
10.1002/cne.902790207
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发表时间：
1989-01-08
影响因子：
2.5
通讯作者：
WRIGHT, DJ
中科院分区：
文献类型：
--
作者：
CASSELL, MD;CHITTICK, CA;WRIGHT, DJ
以往的研究表明，皮质杏仁核神经元在大鼠前边缘（PL）和下边缘（IL）皮质的分布重叠的神经元投射到对侧内侧前额叶皮质（MPC），岛叶皮质，内侧背丘脑和背侧延髓的分布。鉴于分化差的细胞结构的P，IL，和他们的指定之间的allocortex和isocortex过渡的皮质区，本研究试图确定是否有几个皮质和皮质下的预测从这些地区出现的corticoamygdaloid神经元的抵押品。将荧光染料固蓝（FB）或双苯甲亚胺（BB）注射到杏仁复合体和以下区域中：无颗粒和颗粒岛皮质;丘脑背内侧核（MD）;孤束核/延髓背侧（NTS）;对侧杏仁复合体;以及同侧和对侧MPC。投射到同侧杏仁核复合体的神经元主要位于第II层和第V层，第III层细胞较少。伴随注射到岛叶皮质，MD，和NTS标记的神经元的人口安排在椎板部分重叠，但基本上是分开的，corticamygdaloid神经元。岛叶皮质的投射来自第II层和第V层; MD的投射来自第V层和第VI层。Coritcobulbar预测IL起源于神经元排列在一个薄的薄层中的深层V层。很少有神经元投射到杏仁复合体和任何这些领域进行了观察。双侧注射FB和BB到杏仁复合体中，在PL和IL中产生很少的双标记细胞。此外，在第V层，同侧投射coritcoamygdaloid神经元往往比对侧投射神经元位于更深。联合注射BB和FB到杏仁复合体和对侧（但不是同侧）MPC导致大量的双标记神经元在PL和IL的第II，III和V层。对照注射荧光染料到脑脊液标记的PL和IL的浅层中的几个神经元和杏仁复合体（FB）和蛛网膜下腔（BB）的组合注射导致在一个非常小的数量的双标记细胞仅在层II。结果表明，在PL和IL的神经元投射到杏仁复合体的显着比例的发行侧支支配对侧MPC。证据进行了讨论，表明MPC皮质杏仁核神经元的半球间侧支可能有助于相关的杏仁核输出的MPC双边。
Previous studies indicate that the distribution of corticoamygdaloid neurons in the rat prelimbic (PL) and infralimbic (IL) cortices overlaps with the distribution of neurons projecting to the contralateral medial prefrontal cortex (MPC), insular cortex, mediodorsal thalamus, and dorsal medulla. In view of the poorly differentiated cytoarchitecture of P, and IL, and their designation as cortical regions transitional between the allocortex and isocortex, the present study sought to determine whether several cortical and subcortical projections from these areas arise as collaterals of corticoamygdaloid neurons. Injections of the fluorescent dyes Fast Blue (FB) or bisbenzimide (BB) were made into the amygdaloid complex and the following areas: agranular and granular insular cortices; mediodorsal thalamic nucleus (MD); nucleus tractus solitarii/dorsal medulla (NTS); contralateral amygdaloid complex; and ipsilateral and contralateral MPC. Neurons projecting to the ipsilateral amygdaloid complex were located mainly in layers II and V with fewer cells in layer III. Concomitant injections into the insular cortex, MD, and NTS labeled populations of neurons arranged in laminae that partially overlapped with, but were essentially separate from, corticoamygdaloid neurons. Projections to the insular cortex arose from layers II and V; those to MD arose from layers V and VI. Coritcobulbar projections from IL originated from neurons arranged in a thin lamina in the deep part of layer V. Very few neurons projecting to both the amygdaloid complex and any of these areas were observed. Bilateral injections of FB and BB into the amygdaloid complex producted very few double-labeled cells in PL and IL. Further, in layer V, ipsilaterally projecting coritcoamygdaloid neurons tended to be located more deeply than contralaterally projecting neurons. Combined injections of BB and FB into the amygdaloid complex and the contralateral (but not ipsilateral) MPC resulted in significant numbers of double-labeled neurons in layers II, III, and V of PL and IL. Control injections of fluorescent dyes into the cerebrospinal fluid labeled few neurons in the superficial layers of PL and IL and a combined injection into the amygdaloid complex (FB) and subarachnoid space (BB) resulted in a very small number of double-labeled cells in layer II only. The results suggest that a significant proportion of neurons in PL and IL projecting to the amygdaloid complex issue collaterals innervating the contralateral MPC. Evidence is discussed that suggests that the interhemispheric collaterals of MPC corticoamygdaloid neurons may serve to correlate the amygdaloid outputs of the MPC bilaterally.