An antecedent of the MHC-linked genomic region in amphioxus
An antecedent of the MHC-linked genomic region in amphioxus
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DOI：
10.1007/s00251-004-0642-9
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发表时间：
2004-02-01
期刊：
影响因子：
3.2
通讯作者：
Holland, PWH
中科院分区：
文献类型：
--
作者：
Castro, LFC;Furlong, RF;Holland, PWH
人类 6 号染色体上的 MHC 基因位于人类基因组中最具特征的旁系区域之一。围绕该位置 6p21 绘制的许多基因在 HSA 1、9 和 19 上的一个、两个或三个其他染色体位置处具有旁系同源物。这四个染色体区域之间的相似性表明这些联系可能具有适应性意义，和/或它们可能是人类祖先中片段或基因组重复的回声。在这里，我们展示了六个文昌鱼粘粒，包含与人类 MHC 相关旁系区域直系同源的基因，映射到单个文昌鱼染色体。因此，MHC 相关基因组区域的组成早于脊椎动物的起源。
The MHC genes on human chromosome 6 are located within one of the best-characterised paralogy regions of the human genome. Numerous genes mapping around this location, 6p21, have paralogues at one, two or three other chromosomal locations on HSA 1, 9 and 19. The similarity between these four chromosomal regions suggests the linkages may have adaptive significance, and/or they may be echoes of segmental or genome duplication in human ancestry. Here, we show that six amphioxus cosmids, containing genes orthologous to those from the human MHC-linked paralogy regions, map to a single amphioxus chromosome. The composition of the MHC-linked genomic region, therefore, pre-dates vertebrate origins.