Malnutrition inflammation score is associated with coronary artery disease in hepatitis C virus-infected hemodialysis patients
Malnutrition inflammation score is associated with coronary artery disease in hepatitis C virus-infected hemodialysis patients
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DOI：
10.1038/sj.ejcn.1602867
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发表时间：
2008-12-01
影响因子：
4.7
通讯作者：
Haberal, M.
中科院分区：
文献类型：
--
作者：
Elsurer, R.;Afsar, B.;Haberal, M.
目的：丙型肝炎病毒（HCV）感染对动脉粥样硬化的形成具有多种作用。我们调查了抗HCV阳性血液透析（HD）患者的营养不良炎症评分（MIS）是否与冠状动脉疾病（CAD）的存在相关。从医院记录中获得数据，评估患者CAD的风险因素。结果：抗-HCV阳性的HD合并CAD患者的MIS显著高于无CAD患者（8.8 ± 4.0 vs 6.5 ± 2.6，P = 0.02）。冠心病组基础C-反应蛋白（P = 0.002）、峰值C-反应蛋白（P = 0.03）和血清铁蛋白（P = 0.01）均高于非冠心病组，血清白蛋白（P = 0.003）低于非冠心病组。MIS与年龄（r =+0.359，P = 0.001）和病毒载量（r =+0.629，P = 0.0001）呈正相关。单因素Logistic回归分析显示，高龄（比值比（OR）1.093，可信区间（CI）1.039-1.150，P = 0.001），高血压（OR = 3.143，CI：1.084-9.116，P = 0.035），糖尿病（OR 5.344，CI：1.343-21.269，P = 0.017），低甘油三酯高MIS（OR 1.259，CI：1.066-1.488，P = 0.007）与冠心病的发生相关。多变量逻辑回归分析发现年龄（OR 1.090，CI：1.007-1.179，P = 0.033）和MIS是与CAD相关的因素（OR 1.232，CI：1.004-1.511，P = 0.04）。结论：MIS可能与抗HCV阳性HD患者的CAD相关。
Objective: Hepatitis C virus (HCV) infection exerts diverse effects on atherogenesis. We investigated whether malnutrition inflammation score (MIS) is associated with the presence of coronary artery disease (CAD) in anti-HCV-positive hemodialysis (HD) patients.Subjects/Methods: Twenty-two anti-HCV-positive HD patients with CAD and 61 anti-HCV-positive HD patients without CAD (as controls) were included. Data were obtained from hospital records, patients were evaluated for risk factors for CAD. The same physician performed MIS evaluation.Results: MIS of anti-HCV-positive HD patients with CAD were significantly higher than patients without CAD (8.8 +/- 4.0 vs 6.5 +/- 2.6, P = 0.02). In patients with CAD, basal (P = 0.002) and peak C-reactive protein (P = 0.03) and serum ferritin (P = 0.01) concentrations were higher, serum albumin concentrations (P = 0.003) were lower than those patients without CAD. MIS was positively correlated with age (r = +0.359, P = 0.001) and viral load (r = +0.629, P < 0.0001). In univariate logistic regression analysis, advanced age (odds ratios (OR) 1.093, confidence interval (CI): 1.039-1.150, P = 0.001), hypertension (OR = 3.143, CI: 1.084-9.116, P = 0.035), diabetes mellitus (OR 5.344, CI: 1.343-21.269, P = 0.017), low triglyceride (OR 0.992, CI: 0.984-0.999, P = 0.026) and high MIS (OR 1.259, CI: 1.066-1.488, P = 0.007) were associated with the presence of CAD. Multivariate logistic regression analysis identified age (OR 1.090, CI: 1.007-1.179, P = 0.033) and MIS as the factors associated with the presence of CAD (OR 1.232, CI: 1.004-1.511, P = 0.04).Conclusions: MIS may be associated with CAD in anti-HCV-positive HD patients.