Strategies of temozolomide in future glioblastoma treatment.
Strategies of temozolomide in future glioblastoma treatment.
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DOI：
10.2147/ott.s120662
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发表时间：
2017
影响因子：
4
通讯作者：
Lee CY
中科院分区：
文献类型：
--
作者：
Lee CY
多形性胶质母细胞瘤(GBM)可能是最具挑战性的脑肿瘤之一，因为患者通常活不到两年。本综述旨在通过主要涉及替莫唑胺(TMZ)使用的最新策略，及时综述未来可能治疗GBM的方法。虽然这些研究是在体外或在啮齿动物身上进行的，但这些发现共同表明，我们正在朝着为GBM患者开发更有效的治疗方法迈进。到目前为止，纳米颗粒制备是目前研究最广泛的脑靶向给药策略。因此，本综述的第一部分介绍了使用TMZ载药的纳米载体的治疗策略，包括纳米粒、纳米脂质体和纳米粒。除了纳米载体，TMZ与另一种化学试剂或分子之间形成的新络合物也显示出更高的细胞毒性和抗肿瘤活性。另一种方法是通过降低GBM细胞对TMZ的抵抗力，这可以通过抑制细胞内发生的代谢变化、抑制DNA修复蛋白或上调介导自噬的蛋白质来实现。最后，综述整理了一份已证明具有抑制肿瘤细胞生长能力的物质清单。
Glioblastoma multiforme (GBM) may be one of the most challenging brain tumors to treat, as patients generally do not live more than 2 years. This review aimed to give a timely review of potential future treatments for GBM by looking at the latest strategies, involving mainly the use of temozolomide (TMZ). Although these studies were carried out either in vitro or in rodents, the findings collectively suggested that we are moving toward developing a more efficacious therapy for GBM patients. Nanoparticles preparation was, by far, the most extensively studied strategy for targeted brain delivery. Therefore, the first section of this review presents a treatment strategy using TMZ-loaded nanocarriers, which encompassed nanoparticles, nanoliposomes, and nanosponges. Besides nanocarriers, new complexes that were formed between TMZ and another chemical agent or molecule have shown increased cytotoxicity and antitumor activity. Another approach was by reducing GBM cell resistance to TMZ, and this was achieved either through the suppression of metabolic change occurring in the cells, inhibition of the DNA repair protein, or up-regulation of the protein that mediates autophagy. Finally, the review collates a list of substances that have demonstrated the ability to suppress tumor cell growth.