Interfacial engineered gadolinium oxide nanoparticles for magnetic resonance imaging guided microenvironment-mediated synergetic chemodynamic/photothermal therapy
Interfacial engineered gadolinium oxide nanoparticles for magnetic resonance imaging guided microenvironment-mediated synergetic chemodynamic/photothermal therapy
复制标题
用于磁共振成像引导微环境介导的协同化学动力学/光热治疗的界面工程氧化钆纳米颗粒
DOI：
10.1016/j.biomaterials.2019.119379
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发表时间：
2019
期刊：
影响因子：
14
通讯作者：
Zhang Weiguo
中科院分区：
文献类型：
--
作者：
Zhao Zhenghuan;Xu Kai;Fu Chen;Liu Heng;Lei Ming;Bao Jianfeng;Fu Ailing;Yu Yang;Zhang Weiguo
生物材料的界面结构工程化可以提高纳米医学的诊断准确性和治疗效果，甚至可以引入新的结构单元构建治疗诊断剂，因此受到了广泛的关注。纳米磁共振成像对比剂在临床疾病，特别是肿瘤和脑部疾病的诊断中具有广阔的应用前景。因此，对其界面结构进行工程改造，可以形成新的治疗诊断平台，实现有效的疾病诊断和治疗。在这项研究中，我们设计了典型的MRI造影剂，Gd 2 O 3的界面结构，形成一种新的治疗诊断剂与MRI引导的协同化学动力学/光热治疗的改善弛豫。合成的Mn掺杂氧化钆纳米片由于大量有效的顺磁性金属离子以及暴露的Mn和Gd团簇引起的协同增强而表现出改善的T1对比度能力。此外，Mn元素的引入赋予了这种纳米药物类似于Fenton的能力，可以从肿瘤部位过量的H2 O2中产生自由基dotOH，从而实现化学动力学治疗（CDT）。此外，聚多巴胺工程表面允许这种具有有效光热转换能力的纳米药物升高局部温度并加速肿瘤内的芬顿过程，以实现协同CDT/光热治疗（PTT）。本工作为设计磁共振成像引导的协同CDT/PTT实现肿瘤检测和治疗提供了新的指导。
Engineering interfacial structure of biomaterials have drawn much attention due to it can improve the diagnostic accuracy and therapy efficacy of nanomedicine, even introducing new moiety to construct theranostic agents. Nanosized magnetic resonance imaging contrast agent holds great promise for the clinical diagnosis of disease, especially tumor and brain disease. Thus, engineering its interfacial structure can form new theranostic platform to achieve effective disease diagnosis and therapy. In this study, we engineered the interfacial structure of typical MRI contrast agent, Gd2O3, to form a new theranostic agent with improved relaxivity for MRI guided synergetic chemodynamic/photothermal therapy. The synthesized Mn doped gadolinium oxide nanoplate exhibit improvedT1contrast ability due to large amount of efficient paramagnetic metal ions and synergistic enhancement caused by the exposed Mn and Gd cluster. Besides, the introduced Mn element endow this nanomedicine with the Fenton-like ability to generate radical dotOH from excess H2O2in tumor site to achieve chemodynamic therapy (CDT). Furthermore, polydopamine engineered surface allow this nanomedicine with effective photothermal conversion ability to rise local temperature and accelerate the intratumoral Fenton process to achieve synergetic CDT/photothermal therapy (PTT). This work provides new guidance for designing magnetic resonance imaging guided synergetic CDT/PTT to achieve tumor detection and therapy.