Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
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DOI：
10.1016/s0896-6273(01)80035-0
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发表时间：
1999-08-01
期刊：
影响因子：
16.2
通讯作者：
Elmquist, JK
中科院分区：
文献类型：
--
作者：
Elias, CF;Aschkenasi, C;Elmquist, JK
最近的研究加强了下丘脑外侧区（LHA）调节食物摄入和体重的观点。我们确定了瘦素敏感神经元在弓状核的下丘脑（弧），支配LHA使用逆行追踪瘦素管理。我们发现，逆行标记的细胞在Are含有神经肽Y（NPY）mRNA或前阿黑皮素（POMC）mRNA。瘦素给药后，Are中的NPY细胞不表达Fos，但表达细胞因子信号转导抑制因子-3（SOCS-3）mRNA。与此相反，瘦素诱导POMC神经元中的Fos和SOCS-3表达，其中许多也支配LHA。这些研究结果表明，瘦素直接和差异参与神经肽Y和POMC神经元，项目的LHA，连接循环瘦素和神经元，调节进食行为和体重的稳态。
Recent studies have reinforced the view that the lateral hypothalamic area (LHA) regulates food intake and body weight. We identified leptin-sensitive neurons in the arcuate nucleus of the hypothalamus (Arc) that innervate the LHA using retrograde tracing with leptin administration. We found that retrogradely labeled cells in the Are contained neuropeptide Y (NPY) mRNA or proopiomelanocortin (POMC) mRNA. Following leptin administration, NPY cells in the Are did not express Fos but expressed suppressor of cytokine signaling-3 (SOCS-3) mRNA. In contrast, leptin induced both Fos and SOCS-3 expression in POMC neurons, many of which also innervated the LHA. These findings suggest that leptin directly and differentially engages NPY and POMC neurons that project to the LHA, linking circulating leptin and neurons that regulate feeding behavior and body weight homeostasis.