Pathologic and immunohistochemical findings in naturally occurring West Nile Virus infection in horses
Pathologic and immunohistochemical findings in naturally occurring West Nile Virus infection in horses
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DOI：
10.1354/vp.38-4-414
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发表时间：
2001-07-01
影响因子：
2.4
通讯作者：
Arispici, M
中科院分区：
文献类型：
--
作者：
Cantile, C;Del Piero, F;Arispici, M
对美国东北部的4匹马和意大利中部的6匹马的西尼罗黄病毒（WNV）感染的病理学和过氧化物酶免疫组化特征进行了比较。在所有10只动物中，存在轻度至重度脊髓灰质炎脑脊髓炎，伴小T淋巴细胞和较少的巨噬细胞血管周围浸润、多灶性神经胶质结节、中性粒细胞和偶尔的神经元吞噬。在50%的马中观察到血管周围水肿，也在两只动物中肉眼观察到。在4匹美国马中，病变从基底核延伸至脑干和骶脊髓，并且比在6匹意大利马中观察到的病变更严重，这6匹意大利马主要在胸腰段脊髓中有中度至重度病变和轻度菱脑病变。WNV抗原很少，在少数神经元、纤维、神经胶质细胞和巨噬细胞的细胞质中被鉴定。与鸟类中的西尼罗河病毒感染和一些致命的人类感染以及与马的其他重要病毒性脑炎（如甲病毒感染和狂犬病）相比，马中的西尼罗河病毒感染的特征在于几乎没有相关抗原的病变。
The pathologic and peroxidase immunohistochemical features of West Nile flavivirus (WNV) infection were compared in four horses from the northeastern United States and six horses from central Italy. In all 10 animals, there were mild to severe polioencephalomyelitis with small T lymphocyte and lesser macrophage perivascular infiltrate, multifocal glial nodules, neutrophils, and occasional neuronophagia. Perivascular hemorrhages, also noted macroscopically in two animals, were observed in 50% of the horses. In the four American horses, lesions extended from the basal nuclei through the brain stem and to the sacral spinal cord and were more severe than the lesions observed in the six Italian horses, which had moderate to severe lesions mainly in the thoracolumbar spinal cord and mild rhombencephalic lesions. WNV antigen was scant and was identified within the cytoplasm of a few neurons, fibers, glial cells, and macrophages. WNV infection in horses is characterized by lesions with little associated antigen when compared with WNV infection in birds and some fatal human infections and with other important viral encephalitides of horses, such as alphavirus infections and rabies.