EFFECTS OF NALOXONE AND BUPRENORPHINE ON INTRAVENOUS ACETALDEHYDE SELF-INJECTION IN RATS
EFFECTS OF NALOXONE AND BUPRENORPHINE ON INTRAVENOUS ACETALDEHYDE SELF-INJECTION IN RATS
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DOI：
10.1016/0031-9384(84)90168-9
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发表时间：
1984-01-01
影响因子：
2.9
通讯作者：
SINGER, G
中科院分区：
文献类型：
--
作者：
MYERS, WD;NG, KT;SINGER, G
在适当的操作性条件反射下，大鼠可以被诱导自我注射乙醛。麻醉剂拮抗剂纳洛酮（30毫克/公斤）显示，以减少在时间表诱导的乙醛自我注射，但没有影响的barpress反应和自发活动，分别测试大鼠的精细，总和总的活动。丁丙诺啡（0.3和3毫克/公斤），混合激动剂-拮抗剂来自鸦片生物碱蒂巴因，也产生了显着减少乙醛自我注射。然而，丁丙诺啡对未用药大鼠的压迫有显著影响，表明这一发现不应与丁丙诺啡可能参与运动反应无关。虽然这些发现与阿片类药物参与乙醛自我给药的假设一致，但在得出内源性阿片类药物参与乙酰丙酮酸介导的行为的结论时必须谨慎。
Rats can be induced to self-inject acetaldehyde under an appropriate operant conditioning schedule. The narcotic antagonist naloxone (30 mg/kg) is shown to produce a decrease in schedule-induced acetaldehyde self-injection, but was without effect on both barpress responding and spontaneous activity in rats tested individually for fine, gross and total activity. Buprenorphine (0.3 and 3 mg/kg), the mixed agonist-antagonist derived from the opium alkaloid thebaine, also produced a significant decrease in acetaldehyde self-injection. However, a significant effect of buprenorphine on barpressing in otherwise drug naive rats indicated that this finding should not be dissociated from a possible involvement of buprenorphine on motor responding. While the findings are consistent with the hypothesis of opiate involvement in acetaldehyde self-administration, caution must be exercised when drawing conclusions about the participation of endogenous opiates in acetaldehyde-mediated behavior.