Lysyl oxidase: a potential target for cancer therapy
Lysyl oxidase: a potential target for cancer therapy
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DOI：
10.1007/s10787-010-0073-1
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发表时间：
2011-06-01
影响因子：
5.8
通讯作者：
Guruvayoorappan, C.
中科院分区：
文献类型：
--
作者：
Siddikuzzaman;Grace, V. M. Berlin;Guruvayoorappan, C.
赖氨酰氧化酶(LysOX；EC 1.4.3.13，蛋白质-赖氨酸6-氧化酶)是一种胞外铜酶，催化细胞外基质(ECM)中胶原或弹性蛋白的交联，从而调节组织的抗张强度。近年来，LysOX在癌症、伤口愈合、细胞运动、趋化和分化等方面的研究进展反映了其显著的功能多样性，也反映了其在中枢神经系统病理中的作用。然而，最近的报道也显示了LysOX的新作用，包括调节基因转录、运动/迁移和细胞黏附的能力。这些不同的功能使研究人员假设LysOx可能具有多种作用，同时影响细胞外和细胞内的功能(S)。LysOX在肿瘤组织和癌细胞中的下调和上调已被描述，提示LysOX作为肿瘤抑制基因和转移促进基因具有双重作用。在这篇综述中，我们详细解释了赖氨酰氧化酶在肿瘤进展和转移中的作用。
Lysyl oxidases (LysOX; EC 1.4.3.13, protein-lysine 6-oxidases) are extracellular copper enzymes that catalyze the cross-linking of collagens or elastin in the extracellular matrix (ECM), thereby regulating the tensile strength of tissues. Recent implication of LysOX in cancer, wound healing, cell motility, chemotaxis, and differentiation reflects its remarkable functional diversity and also in the central nervous system pathologies. However, recent reports also demonstrated novel roles for LysOX, including the ability to regulate gene transcription, motility/migration, and cell adhesion. These diverse functions have led researchers to hypothesize that LysOX may have multiple roles affecting both extra- and intracellular cell function(s). Both down and up-regulation of LysOX in tumor tissues and cancer cell lines have been described, suggesting a dual role for LysOX as a tumor suppressor, as well as a metastasis promoter gene. In this review we explain in detail the role of lysyl oxidase in tumor progression and metastasis.