Neuronal activity in the second somatosensory cortex of monkeys (Macaca mulatta) during active touch of gratings.
Neuronal activity in the second somatosensory cortex of monkeys (Macaca mulatta) during active touch of gratings.
复制标题
主动触摸光栅期间猴子（猕猴）第二体感皮层的神经元活动。
DOI：
10.1152/jn.1993.70.1.331
复制
发表时间：
1993
影响因子：
2.5
通讯作者：
Burton,H
中科院分区：
文献类型：
--
作者：
Sinclair,RJ;Burton,H
1.在对两只猕猴(Macaca Mulatta)外侧沟上岸的穿刺术中，从第二躯体感觉皮质(SII)分离出细胞。在单细胞记录过程中，动物们进行了一项主动的触摸任务，在这项任务中，他们用指尖摩擦不同凹槽宽度的格栅对，并指出哪个表面更光滑。在这些划水过程中，测量并记录手的运动和向下的作用力。2.在这项调查中，151次穿透提供了对352个细胞的观察，这些细胞对手指的被动刺激或在主动触摸任务执行期间做出反应。与以前的报道一致，SII的感受野(RF)很大，通常是几位数，经常包括部分或全部手，偶尔还包括手臂。在127个完全特征化的细胞中，92个细胞被确定为形态，包括70个皮肤细胞，5个深层细胞，11个太平洋小体细胞和6个关节细胞。作为SII的特征，无法在对被动刺激无反应或其反应随时间变化很大的35个细胞中定义通道。3.SII内79个细胞亚群的反应特性与先前在初级躯体感觉皮质(SI)和丘脑腹后外侧核(VPL)中使用相同程序进行的研究相似。相关分析表明，这些细胞中的29个，就像SI中的一部分细胞一样，对沟槽宽度的变化做出反应，而与力或速度无关。这种选择性可以被认为是一种特征特异性。4.与SI和VPL不同的是，大多数SiI细胞(109/127)可以看到指尖接触小的凸起的金属棒的瞬时反应，这些金属棒区分了横跨栅格的卒中的开始、中间和结束。在与BAR接触的过程中，89个细胞表现出兴奋反应，20个细胞表现出抑制活性。12个细胞对栅格隔绝的条形信号做出反应，这可能是刺激选择性增强的一个例子。5.被动刺激未能激活16个细胞，在某些情况下，这些细胞在任务中对栅格或力有不同的反应。其他九个细胞的反应在中风的选定部分以反应减少或增强的形式表现出任务依赖性的调制。在这些相同的细胞中，只有在行为背景不同的中风其他部分，在类似的刺激条件下，反应没有发生变化。这些类型的选择性反应调节，在我们之前对VPL或SI的研究中没有注意到，表明调节感觉输入的机制可能会影响SII。
1. In penetrations made into the upper bank of the lateral sulcus in two monkeys (Macaca mulatta), cells were isolated from the second somatosensory cortex (SII). During single-cell recordings, animals performed an active touch task in which they rubbed their fingertips over pairs of gratings differing in groove width and indicated which was the smoother surface. Hand motion and downward applied force were measured and recorded during these strokes. 2. In this survey, 151 penetrations provided observations on 352 cells that responded to passive stimulation of the digits or during performance of the active touch task. Consistent with previous reports, receptive fields (RFs) in SII were large, often multi-digit, and frequently included a portion or all of the hand and occasionally the arm. Modality was determined for 92 of 127 fully characterized cells, and included 70 cutaneous, 5 deep, 11 Pacinian corpuscle, and 6 joint cells. Characteristic of SII, modality could not be defined in 35 cells that were unresponsive to passive stimulation or whose responses varied widely over time. 3. Response properties of a subgroup of 79 cells in SII resembled those previously studied in the primary somatosensory cortex (SI) and ventroposterior lateral nucleus of the thalamus (VPL) using identical procedures. Correlation analysis revealed that 29 of these cells, like a portion of cells in SI, responded to changes in groove width independent of force or velocity. This selectivity could be considered a form of feature specificity. 4. In contrast to SI and VPL, transient responses to the fingertips contacting small elevated metal bars, which demarcated the beginning, middle, and end of strokes across the gratings, were seen in a majority of SII cells (109/127). During contact with bars, 89 cells displayed excitatory responses and 20 cells showed suppressed activity. Twelve cells, which responded to bars in isolation from gratings, provided a possible example of increased stimulus selectivity. 5. Passive stimulation failed to activate 16 cells that responded, in some cases differentially to gratings or force, during the task. Responses of nine other cells demonstrated task-dependent modulation in the form of response reduction or enhancement during selected portions of the stroke. In these same cells, response changes did not occur under comparable stimulus conditions in other portions of the stroke that differed only in behavioral context. These types of selective response modulations, not noted in our previous studies of VPL or SI, suggest that mechanisms regulating sensory inputs may affect SII.(ABSTRACT TRUNCATED AT 400 WORDS)