Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men
Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men
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DOI：
10.1053/meta.2002.31332
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发表时间：
2002-04-01
影响因子：
9.8
通讯作者：
Peters, A
中科院分区：
文献类型：
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作者：
Fruehwald-Schultes, B;Oltmanns, KM;Peters, A
二甲双胍的减肥作用已在患有或不患有糖尿病的肥胖受试者中得到证实。这种作用的机制尚不清楚，部分原因可能是，在肥胖和糖尿病患者中，该物质的作用是由于与这些患者独特的内分泌和代谢紊乱之间的复杂相互作用而产生的。为了区分二甲双胍的主要作用和继发作用，我们检查了该物质对正常体重健康受试者的影响。在一项双盲、安慰剂对照、交叉研究中，15 名体重正常的男性接受了二甲双胍（850 毫克，每天两次）或安慰剂治疗，为期 15 天。在治疗期之前和结束时评估人体测量、心理、心血管、内分泌和代谢参数。二甲双胍不影响体重（P = .838）和体脂肪量（P = .916）。然而，二甲双胍后血清瘦素浓度明显降低（P
A weight-reducing effect of metformin has been demonstrated in obese subjects with and without diabetes. The mechanisms of this action are unclear, which may be partly due to the fact that in obese and diabetic patients the substance's effects result from a complex interaction with the distinct endocrine and metabolic disturbances in these patients. To dissociate primary from secondary action of metformin, we examined effects of the substance in normal-weight healthy subjects. Fifteen normal-weight men were treated with metformin (850 mg twice daily) or placebo for a 15-day period in a double-blind, placebo-controlled, cross-over study. Anthropometric, psychologic, cardiovascular, endocrine, and metabolic parameters were assessed before and at the end of the treatment period. Metformin did not affect body weight (P =.838) and body fat mass (P =.916). Yet, serum leptin concentration was distinctly reduced after metformin (P