Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella.
Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella.
复制标题
美洲流行的委内瑞拉马脑炎：隐藏在登革热保护伞下。
DOI：
10.2217/fvl.11.5
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发表时间：
2011
期刊：
影响因子：
3.1
通讯作者：
Weaver SC
中科院分区：
文献类型：
--
作者：
Aguilar PV;Estrada-Franco JG;Navarro-Lopez R;Ferro C;Haddow AD;Weaver SC
委内瑞拉马脑炎（VEE）是拉丁美洲的一种新发传染病。几十年来，在有地方性动物疫病流行的国家记录了疫情，最近实施的监测系统使得在以前未知的VEE活动的国家和地区发现了更多人间病例。在临床上，VEE与登革热和其他虫媒病毒性疾病难以区分，确诊需要使用专门的实验室检测，而在资源有限的地区，这些检测很难负担得起。因此，发展中国家地方性VEE的疾病负担在很大程度上仍然未知，但最近的监测表明，它可能占新热带城市登革热负担的10%，或整个拉丁美洲每年数万例病例。人畜共患病前体细胞可能出现人畜共患病病毒，这进一步突出了加强监测活动、确定蚊子媒介和宿主以及制定有效战略来控制该疾病的必要性。在这篇文章中，我们概述了地方性VEE的现状，这是由地方性流行周期的溢出造成的，我们讨论了疾病控制的公共卫生措施以及未来VEE研究的途径。
Venezuelan equine encephalitis (VEE) is an emerging infectious disease in Latin America. Outbreaks have been recorded for decades in countries with enzootic circulation, and the recent implementation of surveillance systems has allowed the detection of additional human cases in countries and areas with previously unknown VEE activity. Clinically, VEE is indistinguishable from dengue and other arboviral diseases and confirmatory diagnosis requires the use of specialized laboratory tests that are difficult to afford in resource-limited regions. Thus, the disease burden of endemic VEE in developing countries remains largely unknown, but recent surveillance suggests that it may represent up to 10% of the dengue burden in neotropical cities, or tens-of-thousands of cases per year throughout Latin America. The potential emergence of epizootic viruses from enzootic progenitors further highlights the need to strengthen surveillance activities, identify mosquito vectors and reservoirs and develop effective strategies to control the disease. In this article, we provide an overview of the current status of endemic VEE that results from spillover of the enzootic cycles, and we discuss public health measures for disease control as well as future avenues for VEE research.