Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects
Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects
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DOI：
10.1079/bjn20041335
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发表时间：
2005-06-01
影响因子：
3.6
通讯作者：
Westerterp-Plantenga, MS
中科院分区：
文献类型：
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作者：
Adam, TCM;Westerterp-Plantenga, MS
进行本研究以评估与超重/肥胖受试者相比，正常体重受试者在有或没有额外的半乳糖/瓜尔胶刺激的早餐后胰高血糖素样肽-1（GLP-1）释放和食欲是否不同。28名超重/肥胖受试者（BMI 30.3（sd 2.7）kg/m2;年龄44.3（sd 9.7）岁）和30名正常体重受试者（BMI 22.8（sd 1.4），年龄31.5（sd 12.8）岁）参加了一项交叉研究。测量响应于半乳糖（50 g）/瓜尔豆胶的空腹和餐后血浆GLP-1、胰岛素、葡萄糖和游离脂肪酸浓度。（2.5 g）负荷（836 kJ）和标准早餐（1.9兆焦耳; GG），或水（250毫升）和标准早餐（W）每30分钟相对于摄入120分钟。食欲使用100 mm视觉模拟量表进行评估。与W相比，两组中GG后30和60 min的GLP-1浓度显著增加。在W条件下，正常体重受试者的血浆GLP-1浓度高于超重/肥胖受试者（P=0.03）。未观察到组间GG状况存在差异。与超重/肥胖受试者相比，在GG条件下，在30分钟（P=0.02）和60分钟（P=0.04）时，正常体重的饱腹感增加。我们得出结论，在标准早餐后，GLP-1的释放低于超重/肥胖受试者。然而，当早餐中添加半乳糖/瓜尔豆胶时，超重/肥胖受试者的餐后GLP-1释放与正常体重受试者无差异。后者并不反映在主观的饱足感上。对饱腹感激素生理反馈的干扰感知而不是干扰反馈本身可能导致肥胖。
The present study was conducted to assess whether glucagon-like peptide-1 (GLP-1) release and appetite after a breakfast with or without an additional galactose/guar gum stimulation is different in normal-weight compared with overweight/obese subjects. Twenty-eight overweight/obese (BMI 30.3 (sd 2.7) kg/m(2); age 44.3 (sd 9.7) years) and thirty normal-weight subjects (BMI 22.8 (sd 1.4), age 31.5 (SD12.8) years) participated in a crossover study. Fasting and postprandial plasma GLP-1, insulin, glucose and free fatty acid concentrations were measured in response to either a galactose (50 g)/guar gum (2.5 g) load (836 kJ) and a standard breakfast (1.9 MJ; GG), or water (250 ml) and the standard breakfast (W) every 30 min relative to the ingestion for 120 min. Appetite was assessed using 100 mm visual analogue scales. GLP-1 concentrations were significantly increased after GG at 30 and 60 min compared with W in both groups. Plasma GLP-1 concentrations in the W condition were higher in normal-weight than overweight/obese subjects (P=0.03). No difference was observed in the GG condition between groups. Satiety was increased in normal-weight compared with overweight/obese subjects in the GG condition at 30 (P=0.02) and 60 (P=0.04) min. We conclude that after a standard breakfast with water, GLP-1 release was lower in the overweight/obese than the normal-weight subjects. However, postprandial GLP-1 release in overweight/obese subjects was no different from that of normal-weight subjects when galactose/guar gum was added to the breakfast. The latter was not mirrored by subjective feelings of satiety. Disturbed perception of the physiological feedback of a satiety hormone rather than disturbed feedback itself might contribute to obesity.