Wound Healing Activity of the Galls of Quercus infectoria Olivier
Wound Healing Activity of the Galls of Quercus infectoria Olivier
复制标题
没食栎瘿的伤口愈合活性
DOI：
10.18311/jnr/2002/345
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发表时间：
2002
影响因子：
--
通讯作者：
K. Alagawadi
中科院分区：
文献类型：
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作者：
S. Jalalpure;M. Patil;K. Alagawadi
目的：筛选没食子树瘿不同提取物对白化大鼠切口、切除和死腔（肉芽）伤口模型的创面愈合活性。材料和方法：对没食子树瘿的粗水提取物及其三种不同的粗馏分、石油醚（40°-60°C）、溶剂醚、乙酸乙酯进行各种初步植物成分测试，并以100mg/kg的剂量筛选白化大鼠切口、切除和死腔（肉芽）伤口模型的伤口愈合特性。结果：在没食子栎的水提物及其各部分中发现单宁、类黄酮、类固醇和碳水化合物。在重新缝合的切口伤口模型中，与对照相比，水提取物及其级分显示出显着的断裂强度（P<0.01）。在切除伤口参数中，与对照和有机部分相比，水提取物促进更好的伤口愈合（96.36%）。草髓诱导的肉芽肿的断裂强度研究结果表明，在水提取物与溶剂醚部分一起的情况下具有显着的活性（P<0.01）。结论：从所得结果可以看出，没食子树瘿的水提取物及其部位具有显着的伤口愈合性能。还可以得出结论，类黄酮可能负责伤口愈合活性。
Objective: To screen the wound healing activity of different extracts of galls of Quercus infectoria on incision, excision and dead space (granulation) wound models in albino rats. Materials and method: Crude aqueous extract of Quercus infectoria galls and its three different crude fractions, petroleum ether (40°-60°C), solvent ether, ethyl acetate were tested for various preliminary phytoconstituents and were screened at dose of 100mg/kg for wound healing properties in incision, excision and dead space (granulation) wound models in albino rats. Results: Tannins, flavonoids, steroids and carbohydrates were found to be present in aqueous extract and its various fractions of galls of Quercus infectoria . In resutured incision wound models aqueous extract and its fractions showed significant (P<0.01) breaking strength compared to control. In excision wound parameters the aqueous extract promotes better wound healing (96.36%) compared to control and organic fractions. Breaking strength of the grass pith induced granuloma studies the results show significant (P<0.01) activity in case of aqueous extract along with solvent ether fraction. Conclusion: From the results obtained, it can be observed that aqueous extract and its fractions of galls of Quercus infectoria have significant wound healing property. Also it can be concluded that flavonoids may be responsible for wound healing activity.