Cerenkov imaging.
Cerenkov imaging.
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DOI：
10.1016/b978-0-12-411638-2.00006-9
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发表时间：
2014
影响因子：
--
通讯作者：
Thorek, Daniel L. J.
中科院分区：
文献类型：
--
作者：
Das, Sudeep;Grimm, Jan;Thorek, Daniel L. J.
切伦科夫发光 (CL) 最近已被用于多种医学应用，例如临床相关医用同位素的成像和治疗。医用同位素的使用范围相当广泛，并且还在不断扩大。体内光的产生是有用的，因为它规避了激发光的深度限制。切伦科夫发光成像 (CLI) 的基础设施比正电子发射断层扫描 (PET) 便宜得多，并且对于表面结构成像特别有用。成像基本上可以使用针对低光条件优化的灵敏相机来完成，并且它具有比任何其他核成像方式更好的分辨率。 CLI 已被证明可以通过临床环境中经常使用的 PET 同位素 (18F-FDG) 有效诊断疾病。切伦科夫发光断层扫描、切伦科夫发光内窥镜和术中切伦科夫成像也得到了探索，并取得了积极的结论，扩大了当前的应用范围。 Cerenkov 也被用来提高 PET 成像分辨率，因为两者的来源都是所使用的放射性同位素。智能成像剂的设计基于使用小分子和纳米颗粒调节切伦科夫信号，可以更好地了解肿瘤生物学。
Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope (18F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.