Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child
Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child
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DOI：
10.1128/jvi.78.16.8927-8930.2004
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发表时间：
2004-08-01
影响因子：
5.4
通讯作者：
Goulder, PJR
中科院分区：
文献类型：
--
作者：
Feeney, ME;Tang, Y;Goulder, PJR
人类免疫缺陷病毒1型(HIV-1)蛋白中细胞毒性T淋巴细胞(CTL)逃逸突变的出现与艾滋病的进展有关，但很难确定病毒突变是病毒复制增加的原因还是结果。在这里，我们描述了一名围产期感染艾滋病毒的儿童，他的血浆病毒载量保持在
The emergence of cytotoxic T-lymphocyte (CTL) escape mutations in human immunodeficiency virus type 1 (HIV-1) proteins has been anecdotally associated with progression to AIDS, but it has been difficult to determine whether viral mutation is the cause or the result of increased viral replication. Here we describe a perinatally HIV-infected child who maintained a plasma viral load of