Urinary excretion of MPTP and its primary metabolites in mice.
Urinary excretion of MPTP and its primary metabolites in mice.
复制标题
MPTP 及其主要代谢物在小鼠体内的尿液排泄。
DOI：
10.1016/0024-3205(88)90257-3
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发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
J. A. Wilson
中科院分区：
文献类型：
--
作者：
Y. Lau;J. Crampton;J. A. Wilson
Mice were injected with single doses of MPTP (15 mg/kg, s.c.) containing one u̧Ci of [3H]methyl-MPTP. Approximately 42% of the total injected [3H] was detected in the urine within 3 hours after drug administration. The early urine samples were analyzed using high pressure liquid chromatography. MPTP N-oxide was identified as a major metabolite, with trace amounts of MPP+and MPTP also detected. The urinary volume and excretion of MPTP metabolites were inhibited by pretreating the animals with probenecid (250 mg/kg, i.p.). These results indicate that large amounts of injected MPTP are rapidly metabolized in the periphery by liver enzymes to form MPTP N-oxide.
