Promiscuous binding of extracellular peptides to cell surface class I MHC protein
Promiscuous binding of extracellular peptides to cell surface class I MHC protein
复制标题
DOI：
10.1073/pnas.1201586109
复制
发表时间：
2012-03-20
影响因子：
11.1
通讯作者：
Cohen, Richard J.
中科院分区：
文献类型：
--
作者：
Eisen, Herman N.;Hou, Xun Helen;Cohen, Richard J.
根据对短肽(8-10MERS)与I类MHC蛋白结合的测量得出的算法表明，I类MHC蛋白的结合槽，如K-b，可以结合100多万种不同的具有显著亲和力的多肽(
Algorithms derived from measurements of short-peptide (8-10 mers) binding to class I MHC proteins suggest that the binding groove of a class I MHC protein, such as K-b, can bind well over 1 million different peptides with significant affinity (