Methionine restriction sensitizes cancer cells to immunotherapy.
Methionine restriction sensitizes cancer cells to immunotherapy.
复制标题
DOI：
10.1002/cac2.12492
复制
发表时间：
2023-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
代谢改变是人类癌症的一个决定性特征，在临床上具有重要的诊断价值。一种广泛使用的诊断工具是[18F]脱氧葡萄糖正电子发射断层扫描（FDG-PET）扫描，它是基于癌细胞更喜欢摄取葡萄糖的事实，这种现象被称为Warburg效应。除了葡萄糖代谢的显著变化外，癌细胞在氨基酸代谢方面也表现出明显的变化。临床研究表明，与FDG-PET扫描相比，[11C]-蛋氨酸（Met-PET） PET成像对肿瘤的检测信号更强，特异性更高。癌细胞对外源性蛋氨酸的依赖被称为霍夫曼效应[2]，强调蛋氨酸成瘾是癌症的基本和普遍标志。蛋氨酸是一种含硫的必需氨基酸，是多种代谢的关键底物。缩写：cGAS-STING，环GMP-AMP合成酶(cGAS) -干扰素基因刺激因子（STING）；FDG-PET，[18F]脱氧葡萄糖正电子发射断层扫描；m6A N6-methyladenosine;Met-PET，[11C]-蛋氨酸正电子发射断层扫描；MR，蛋氨酸限制；PD-1，程序性死亡-1；PD-L1， PD-1配体长官,S-adenosyl-homocysteine;山姆,S-adenosylmethionine;T细胞活化的v域Ig抑制因子VISTA；YTHDF1， ythn6 -甲基腺苷RNA结合蛋白
Altered metabolism is a defining characteristic of human cancer and holds significant diagnostic value in the clinic. A widely utilized diagnostic tool is the [18F] deoxyglucosepositron emission tomography (FDG-PET) scan, which is based on the fact that cancer cells prefer to uptake glucose, a phenomenon known as the Warburg effect. In addition to the notable shifts in glucose metabolism, cancer cells exhibit distinct alterations in amino acid metabolism. Clinical studies have shown that PET imaging with [11C]-methionine (Met-PET) provides stronger signals and higher specificity in tumor detection compared to the FDG-PET scan [1]. The dependence of cancer cells on exogenous methionine is referred to as the Hoffman effect [2], underscoring methionine addiction as a fundamental and general hallmark of cancer. Methionine is a sulfur-containing essential amino acid and serves as a critical substrate in multiple metabolicAbbreviations: cGAS-STING, Cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING); FDG-PET,[18F] deoxyglucose-positron emission tomography; m6A, N6-methyladenosine; Met-PET,[11C]-methionine-positron emission tomography; MR, methionine restriction; PD-1, programmed death-1; PD-L1, PD-1 ligand; SAH, S-adenosyl-homocysteine; SAM, S-adenosylmethionine; VISTA, V-domain Ig suppressor of T cell activation; YTHDF1, YTH N6-methyladenosine RNA binding protein 1..
登录
查看更多内容
影响因子：
64.8
作者：
Gao, Xia;Sanderson, Sydney M.;Locasale, Jason W.
通讯作者：
Locasale, Jason W.
DOI：
10.1073/pnas.79.14.4248
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
COALSON, DW;MECHAM, JO;HOFFMAN, RM
通讯作者：
HOFFMAN, RM
DOI：
10.1073/pnas.73.5.1523
发表时间：
1976-01-01
影响因子：
11.1
作者：
HOFFMAN, RM;ERBE, RW
通讯作者：
ERBE, RW
蛋氨酸缺乏通过改变免疫检查点转录本的 m6A 甲基化来促进抗肿瘤免疫
影响因子：
24.5
作者：
Li, Ting;Tan, Yue-Tao;Chen, Yan-Xing;Zheng, Xiao-Jun;Wang, Wen;Liao, Kun;Mo, Hai-Yu;Lin, Junzhong;Yang, Wei;Piao, Hai-Long;Xu, Rui-Hua;Ju, Huai-Qiang
通讯作者：
Ju, Huai-Qiang
影响因子：
9.3
作者：
Singhal, Tarun;Narayanan, Tanjore K.;Mantil, Joseph C.
通讯作者：
Mantil, Joseph C.