[A new exanthematous disease in newborn infants caused by exotoxins producing Staphylococcus aureus; exotoxins production of the isolates and serum levels of antitoxin antibody in the patients and umbilical cord blood].
[A new exanthematous disease in newborn infants caused by exotoxins producing Staphylococcus aureus; exotoxins production of the isolates and serum levels of antitoxin antibody in the patients and umbilical cord blood].
复制标题
产外毒素金黄色葡萄球菌引起的一种新的新生儿出疹性疾病；
DOI：
10.11150/kansenshogakuzasshi1970.73.893
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
J. Sugiyama
中科院分区：
文献类型：
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作者：
T. Okada;S. Furukawa;K. Miwa;R. Sakai;J. Sugiyama
最近，在日本，新的新生儿外分泌性疾病被阐明是由葡萄球菌的超临界外毒素，主要是TSST-1。本文对43株沙门氏菌的外毒素进行了研究。方法：采用金黄色葡萄球菌肠毒素A、B、C（SEA、SE B、SEC）和中毒性休克综合征毒素1（TSST-1）抗体滴度测定法，检测新生儿脐带血中TSST-1抗体滴度。结果如下：1.从患者分离的43株MRSA中，34株（79%）为产SEC和TSST-1的MRSA，5株（12%）为产SEB、SEC和TSST-1的MRSA，1株（2%）为产SEB和TSST-1的MRSA，2株（12%）为产SEB而不产TSST-1的MSSA。1株（2%）为MSSA，产生SEC和TSST-1。2. 16例新生儿表现出典型的血小板减少症的临床症状和实验室检查结果，与对照组（足月儿脐带血）相比，SEC和TSST-1产生MRSA分离株在发病时具有显著低的抗TSST-1抗体滴度（p < 0.05）：TSST-1似乎是该疾病的病原体。在两个新生儿患外显性疾病，与SEB和非TSST-1生产MSSA分离株，抗SEB抗体滴度低，在发病时，所以SEB出现的病原体的疾病。3.在日本，在约70%的足月婴儿的脐带血样本中发现低抗TSST-1抗体滴度;在仅约10%的样本中发现低抗SEB或抗SEC抗体滴度，即许多足月婴儿具有抗SEB和抗SEC抗体。大多数S。从新生儿外生性疾病中分离的金黄色葡萄球菌是产肠毒素和TSST-1的MRSA。我们通过测定抗毒素抗体滴度的研究结果表明，SEB和SEC可能不是致病性的，但TSST-1被认为是大多数外生性疾病的原因。在新生儿和早产儿病房中产生TSST-1的MRSA的流行是日本这种疾病高发的主要原因，而与抗肠毒素抗体滴度相比，母亲对TSST-1的抗体滴度较低也可能是一个诱发因素。
Recently, in Japan newly neonatal exanthematous disease was elucidated to be caused by staphyloccocal supcrantigcnic exotoxins, mainly TSST-1. We studied exotoxins producibility of 43 strains of S. aureus isolated from neonates with exanthematous disease and examined antibody titers to staphylococcal enterotoxin A, B, C (SEA, SEB, SEC) and toxic shock syndrome toxin 1 (TSST-1) of the patients and control (umbilical cord blood from term infants). The results were as follows 1.34 of 43 strains (79%) isolated from the patients were SEC and TSST-1 producing MRSA, 5 strains (12%) were SEB, SEC, and TSST-1 producing MRSA, 1 strain (2%) was SEB and TSST-1 producing MRSA, 2 strains (12%) were SEB producing MSSA and did not produce TSST-1. The 1 strain (2%) was MSSA which produced SEC and TSST-1. 2. 16 neonates with exanthematous disease, who showed typical clinical signs and laboratry findings of thrombocytopenia, with SEC and TSST-1 producing MRSA isolates had significantly low anti-TSST-1 antibody titers at onset (p < 0.05), compared with the control (umbilical cord blood from term infants): TSST-1 appeared to the causative agent for the disease. In two neonates with exanthematous disease, with SEB- and non- TSST-1-producing MSSA isolates, anti-SEB antibody titers were low at onset, so SEB appeared to the causative agent for the disease. 3. In Japan, low anti-TSST-1 antibody titers were found in the umbilical blood samples from about 70% of term infants; and low anti-SEB or anti-SEC antibody titers were found in samples from only about 10% of them, that is, a number of term infants had anti-SEB and anti-SEC antibodies. The majority of S. aureus isolated from neonates with exanthematous disease were enterotoxin- and TSST-1-producing MRSAs. The results of our study by measuring antitoxin antibody titers suggested that SEB and SEC might not be pathogenically responsible, but TSST-1 was considered to be responsible for the majority of exanthematous disease. Prevalence of TSST-1-producing MRSA in the neonatal and premature baby ward is the main cause for the high incidence of this disease in Japan, whereas the low antibody titer to TSST-1 in the mother, in comparison with the anti-enterotoxin antibody titers, may also be a predisposing factor.