Interaction between CD14 and LXRβ genes modulates Alzheimer's disease risk
Interaction between CD14 and LXRβ genes modulates Alzheimer's disease risk
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DOI：
10.1016/j.jns.2007.08.001
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发表时间：
2008-01-15
影响因子：
4.4
通讯作者：
Combarros, Onofre
中科院分区：
文献类型：
--
作者：
Rodriguez-Rodriguez, Eloy;Sanchez-Juan, Pascual;Combarros, Onofre
小胶质细胞激活的慢性炎症过程会导致与阿尔茨海默病 (AD) 相关的神经变性。 CD14 和 LXR β 是参与调节小胶质细胞响应细菌感染或脂多糖刺激的炎症反应的受体。在一项对 266 名 AD 患者和 273 名健康对照者进行的病例对照研究中，我们检查了 CD14 (-260) 多态性和 LXR beta（内含子 5）多态性之间的组合基因效应是否可能导致 AD 易感性。携带 CD14 (-260) C/C 和 LXR beta（内含子 5）G/G 基因型的受试者患 AD 的风险比不带这些风险基因型的受试者低六倍（OR 0.16，95% CI 0.04-0.67，p=0.01）。这些数据支持先天免疫反应基因在 AD 风险中的作用。 (C) 2007 Elsevier B.V. 保留所有权利。
A chronic inflammatory process with activation of microglial cells contribute to the neurodegeneration associated with Alzheimer's disease (AD). CD14 and LXR beta are receptors involved in the regulation of inflammatory responses of microglia in response to bacterial infection or lipopolysaccharide stimulation. In a case-control study in 266 AD patients and 273 healthy controls, we examined whether the combined gene effects between CD14 (-260) polymorphism and LXR beta (intron 5) polymorphism might be responsible for susceptibility to AD. Subjects carrying both the CD14 (-260) C/C and the LXR beta (intron 5) G/G genotypes had asixtimes lower risk of developing AD than subjects without these risk genotypes (OR 0.16, 95% CI 0.04-0.67,p=0.01). These data support a role for innate immune response genes in risk for AD. (C) 2007 Elsevier B.V. All rights reserved.