Meaning of Visualizing Retinal Cone Mosaic on Adaptive Optics Images
Meaning of Visualizing Retinal Cone Mosaic on Adaptive Optics Images
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DOI：
10.1016/j.ajo.2014.09.043
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发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Gaudric, Alain
中科院分区：
文献类型：
--
作者：
Jacob, Julie;Paques, Michel;Gaudric, Alain
中心点 目的：探讨自适应光学图像上视网膜锥体马赛克的解剖相关性。中心点设计：回顾性非连续观察病例系列。中心点方法：对 6 例自适应光学上锥体马赛克局灶性改变的患者的多模态成像图进行回顾性检查。视网膜疾病包括急性后多灶性鳞状色素上皮病 (n = 1)、羟氯喹视网膜病 (n = 1) 和 2 型黄斑毛细血管扩张症 (n = 4)。使用泛光照明自适应光学相机获得高分辨率视网膜图像。使用标准成像方式记录图像：彩色和无红眼底相机摄影；红外反射扫描激光检眼镜、荧光素血管造影、吲哚菁绿血管造影和谱域光学相干断层扫描（OCT）图像。中心点结果：在OCT上，在病灶边缘区，观察到交指区消失，而椭圆体区保留。图像记录表明，叉指区的这种衰减与自适应光学图像上锥形马赛克的消失共定位。在 1 例病例中，经过 2 个月的随访后，叉指区的恢复与锥体马赛克的恢复平行。中心点结论：我们的结果表明，叉指区可以对锥体感光器马赛克的反射率做出重大贡献。自适应光学图像上没有视锥细胞并不一定意味着感光细胞死亡。 (C) 2015 年，Elsevier Inc. 保留所有权利。
center dot PURPOSE: To explore the anatomic correlation of the retinal cone mosaic on adaptive optics images.center dot DESIGN: Retrospective nonconsecutive observational case series.center dot METHODS: A retrospective review of the multimodal imaging charts of 6 patients with focal alteration of the cone mosaic on adaptive optics was performed. Retinal diseases included acute posterior multifocal placoid pigment epitheliopathy (n = 1), hydroxychloroquine retinopathy (n = 1), and macular telangiectasia type 2 (n = 4). High-resolution retinal images were obtained using a flood-illumination adaptive optics camera. Images were recorded using standard imaging modalities: color and red-free fundus camera photography; infrared reflectance scanning laser ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography (OCT) images.center dot RESULTS: On OCT, in the marginal zone of the lesions, a disappearance of the interdigitation zone was observed, while the ellipsoid zone was preserved. Image recording demonstrated that such attenuation of the interdigitation zone co-localized with the disappearance of the cone mosaic on adaptive optics images. In 1 case, the restoration of the interdigitation zone paralleled that of the cone mosaic after a 2-month follow-up.center dot CONCLUSION: Our results suggest that the interdigitation zone could contribute substantially to the reflectance of the cone photoreceptor mosaic. The absence of cones on adaptive optics images does not necessarily mean photoreceptor cell death. (C) 2015 by Elsevier Inc. All rights reserved.