Oligodendrocyte precursor cell maturation: role of adenosine receptors.
Oligodendrocyte precursor cell maturation: role of adenosine receptors.
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少突胶质前体细胞成熟：腺苷受体的作用。
DOI：
10.4103/1673-5374.306058
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发表时间：
2021-09
影响因子：
6.1
通讯作者：
Coppi E
中科院分区：
文献类型：
--
作者：
Cherchi F;Pugliese AM;Coppi E
少突胶质细胞形成的髓鞘允许大脑中的快速突触传递，它们的变性导致脱髓鞘疾病，如多发性硬化症。髓鞘再形成需要少突胶质细胞祖细胞分化为成熟的少突胶质细胞，但是在慢性神经退行性疾病中，由于不利的环境，髓鞘再形成失败。因此，需要一种促使少突胶质细胞祖细胞向髓鞘化少突胶质细胞分化的策略。神经调节剂腺苷及其受体（A1、A2A、A2B和A3受体：A1R、A2AR、A2BR和A3R）是髓鞘再生过程中的重要介质。已知A1Rs促进少突胶质细胞祖细胞成熟和迁移，而A3Rs启动少突胶质细胞祖细胞的凋亡。我们的研究小组通过证明A2AR和A2BR通过减少细胞分化所需的电压依赖性K+电流来抑制少突胶质细胞祖细胞成熟，从而为该领域做出了贡献。本文综述了腺苷受体配体在脱髓鞘疾病如多发性硬化中的潜在治疗靶点。
Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, in chronic neurodegenerative disorders, remyelination fails due to adverse environment. Therefore, a strategy to prompt oligodendrocyte progenitor cell differentiation towards myelinating oligodendrocytes is required. The neuromodulator adenosine, and its receptors (A1, A2A, A2B and A3 receptors: A1R, A2AR, A2BR and A3R), are crucial mediators in remyelination processes. It is known that A1Rs facilitate oligodendrocyte progenitor cell maturation and migration whereas the A3Rs initiates apoptosis in oligodendrocyte progenitor cells. Our group of research contributed to the field by demonstrating that A2AR and A2BR inhibit oligodendrocyte progenitor cell maturation by reducing voltage-dependent K+ currents necessary for cell differentiation. The present review summarizes the possible role of adenosine receptor ligands as potential therapeutic targets in demyelinating pathologies such as multiple sclerosis.
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16.6
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