The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling
The Possible Crosstalk of MOB2 With NDR1/2 Kinases in Cell Cycle and DNA Damage Signaling
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DOI：
10.4172/2576-1471.1000125
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发表时间：
2016-09
期刊：
影响因子：
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通讯作者：
R. Gundogdu;A. Hergovich
中科院分区：
文献类型：
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作者：
R. Gundogdu;A. Hergovich
本文就信号转导分子Mps one binder 2（MOB 2）在细胞周期调控和DNA损伤反应（DDR）中的作用发表了自己的看法。我们最近发现，需要内源性MOB 2来防止内源性DNA损伤的积累，以防止不希望的、可能有害的细胞周期检查点的激活。在这方面，值得注意的是，MOB 2已经在生物化学上与NDR 1/2（aka STK 38/STK 38 L）蛋白激酶的调节相关联，这些蛋白激酶本身在细胞周期的不同步骤中具有功能。因此，我们在这篇文章中推测MOB 2与细胞周期和DDR信号中的NDR 1/2激酶的可能联系。
This article is the authors’ opinion of the roles of the signal transducer Mps one binder 2 (MOB2) in the control of cell cycle progression and the DNA Damage Response (DDR). We recently found that endogenous MOB2 is required to prevent the accumulation of endogenous DNA damage in order to prevent the undesired, and possibly detrimental, activation of cell cycle checkpoints. In this regard, it is noteworthy that MOB2 has been linked biochemically to the regulation of the NDR1/2 (aka STK38/STK38L) protein kinases, which themselves have functions at different steps of the cell cycle. Therefore, we are speculating in this article about the possible connections of MOB2 with NDR1/2 kinases in cell cycle and DDR Signaling.