AGING CHANGES IN CD-1 HAM-ICR MICE REARED UNDER STANDARD LABORATORY CONDITIONS
AGING CHANGES IN CD-1 HAM-ICR MICE REARED UNDER STANDARD LABORATORY CONDITIONS
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DOI：
10.1093/jnci/55.1.37
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
WEISBURGER, EK
中科院分区：
文献类型：
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作者：
HOMBURGER, F;RUSSFIELD, AB;WEISBURGER, EK
对300只CD®-1 HaM/ICR小鼠进行了为期2年的观察，对99只雄性和102只雌性进行了有益的尸检。16个月时雄性和18个月时雌性的死亡率分别为50%。在进行尸检的小鼠中，雄性和雌性的肿瘤总发病率分别为54%和75%，大多数肿瘤发生在18个月后。腺瘤或肺腺癌是最常见的，其次是淋巴网状瘤、血管瘤、肝癌、皮下纤维肉瘤和乳腺腺癌。在一半的雄性和雌性小鼠中都发现了一定程度的淀粉样变性，雄性小鼠在8个月大时开始，雌性小鼠在12个月大时开始。在小组小鼠中肿瘤发病率的可变性强调了对足够样本的需要。
Three hundred CD®-1 HaM/ICR mice were observed for 2 years, and useful necropsies were done on 99 males and 102 females. Mortality was 50% at 16 months in the males and 18 months in the females. Among mice that came to autopsy, total tumor incidence was 54% for males and 75% for females, with most neoplasms occurring after 18 months. Adenomas or adenocarcinomas of the lung were the most frequent, followed by lymphoreticular tumors, vascular tumors, hepatomas, subcutaneous fibrosarcomas, and adenocarcinomas of the mammary glands. Some degree of amyloidosis was seen in half the mice of both sexes, beginning at 8 months in males and 12 months in females. Variability in tumor incidence among small groups of mice emphasized the need for adequate samples.