LINGO1 and risk for essential tremor: Results of a meta-analysis of rs9652490 and rs11856808
LINGO1 and risk for essential tremor: Results of a meta-analysis of rs9652490 and rs11856808
复制标题
DOI：
10.1016/j.jns.2012.02.030
复制
发表时间：
2012-06-15
影响因子：
4.4
通讯作者：
Agundez, Jose A. G.
中科院分区：
文献类型：
--
作者：
Javier Jimenez-Jimenez, Felix;Garcia-Martin, Elena;Agundez, Jose A. G.
背景/目标：最近，一项全基因组关联研究揭示了LINGO 1 rs 9652490和rs 11856808多态性与冰岛人发生特发性震颤（ET）的风险之间存在显著的统计学关联。由于进一步的关联研究结果存在争议，我们进行了一项荟萃分析，包括所有已发表的与这些多态性相关的ET风险研究。荟萃分析包括11项LINGO 1 rs 9652490与（3972例ET患者，20，714例对照）和7项LINGO 1 rs 11856808与ET风险之间的关联研究（2076名ET患者，18，792名对照），并通过使用软件Meta-Disc 1.1.1（http：//www.hrc.es/pathacion/metadisc.html; Unit of Clinical Statistics，Hospital Ramon y Cajal，马德里，西班牙）进行。使用Q统计量检验研究之间在关联度方面的异质性。总系列中rs 9652490和rs 11856808的总体诊断比值比（OR）和95%置信区间（Cl）分别为，1.17（1.00-1.36）（p = 0.069）和1.20（1.05-1.36）（p =0.016）。在排除了发现系列中冰岛人的数据（这是rs 9652490多态性高度异质性的原因）后，OR和CI分别为1.10（0.97-1.26）（p=0.063）和1.12（0.99-1.27）（p=0.034）。家族性ET患者rs 9652490和rs 11856808的总体OR和95%CI分别为1.27（1.03-1.57）（p =0.014）和1.21（1.10-1.44）（p = 0.031）。荟萃分析的结果表明LINGO 1 rs 11856808多态性与ET和家族性ET的风险之间存在关系，而rs 9652490多态性仅与家族性ET相关。(C)2012爱思唯尔有限公司版权所有。
Background/objectives: Recently, a genome-wide association study revealed a significant statistical association between LINGO1 rs9652490 and rs11856808 polymorphisms and the risk of developing essential tremor (ET) in Icelandic people. Because the results of further association studies were controversial, we conducted a meta-analysis including all the studies published on the risk of ET related with these polymorphisms.Methods: The metaanalysis included 11 association studies between LINGO1 rs9652490 (3972 ET patients, 20,714 controls) and 7 association studies between LINGO1 rs11856808, and risk for ET (2076 ET patients, 18,792 controls), and was carried out by using the software Meta-Disc 1.1.1 (http://www.hrc.es/investigacion/metadisc.html; Unit of Clinical Statistics, Hospital Ramon y Cajal, Madrid, Spain). Heterogeneity between studies in terms of degree of association was tested using the Q-statistic.Results: Global diagnostic odds-ratios (ORs) and 95% confidence intervals (Cl) for rs9652490 and rs11856808 of the total series were, respectively, 1.17 (1.00-1.36) (p = 0.069) and 1.20 (1.05-1.36) (p =0.016). After excluding data on Icelandic people of the discovery series (that was responsible of a high degree of heterogeneity for rs9652490 polymorphism), the ORs and Cl were 1.10 (0.97-1.26) (p=0.063) and 1.12 (0.99-1.27) (p=0.034). Global ORs and 95% Cl for rs9652490 and rs11856808 of familial ET patients were, respectively, 1.27 (1.03-1.57) (p =0.014) and 1.21 (1.10-1.44) (p = 0.031).Conclusions: The results of the meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and the risk for ET and for familial ET, while rs9652490 polymorphism was only related with the risk for familial ET. (C) 2012 Elsevier B.V. All rights reserved.