A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia.
A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia.
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DOI：
10.1016/j.neuron.2010.02.014
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发表时间：
2010-03-11
期刊：
影响因子：
16.2
通讯作者：
Kandel E
中科院分区：
文献类型：
--
作者：
Simpson EH;Kellendonk C;Kandel E
精神分裂症的认知症状在很大程度上对目前的治疗有抗药性，因此是这种疾病的终身负担。认知症状的研究通常集中在前额皮质，因为它对执行功能和工作记忆的重要性-缺陷的关键组成部分。纹状体-皮层回路的作用以及纹状体本身受到的关注要少得多。在这里，我们回顾了长期以来纹状体及其皮层连接对复杂认知至关重要的证据，并讨论了纹状体可能参与认知症状的新证据。最后，我们建议如何通过小鼠模型来验证早期纹状体功能障碍对精神分裂症认知症状的影响。
The cognitive symptoms of schizophrenia are largely resistant to current treatment and are thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused on prefrontal cortex because of its demonstrated importance for executive function and working memory—key components of the deficit. The role of striatal-cortical circuitry and therefore the striatum itself has received much less attention. Here we review longstanding evidence that the striatum and its cortical connections are critical for complex cognition and discuss emerging evidence of the striatum’s potential involvement in cognitive symptoms. Finally, we suggest how mouse models might test ideas about the contribution of early striatal dysfunction to the cognitive symptoms of schizophrenia.