Effects of different corticosteroids on the development of osteonecrosis in rabbits
Effects of different corticosteroids on the development of osteonecrosis in rabbits
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DOI：
10.1093/rheumatology/keh505
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发表时间：
2005-03-01
期刊：
影响因子：
5.5
通讯作者：
Iwamoto, Y
中科院分区：
文献类型：
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作者：
Miyanishi, K;Yamamoto, T;Iwamoto, Y
目标.股骨头坏死（ON）是接受皮质类固醇治疗的患者发生的毁灭性并发症。本研究探讨了三种皮质类固醇对兔ON发展的影响。39只家兔肌肉注射一次25 mg/kg泼尼松龙琥珀酸钠（PSL; 13只家兔）、20 mg/kg醋酸甲泼尼龙（MPSL; 13只家兔）或20 mg/kg曲安奈德（TR; 13只家兔）。注射皮质类固醇4周后，取双侧股骨和肱骨进行组织病理学检查，观察ON的存在情况，并在注射皮质类固醇前后进行血液学检查。MPSL治疗组（17/26例股骨近端，65%）与TR（4/26例，15%）或PSL（3/26例，12%）治疗组相比，股骨近端ON发生率显著增加（P
Objectives. Osteonecrosis (ON) of the femoral head is a devastating complication occurring in patients receiving corticosteroid treatment. This study examined the effect of three corticosteroids on the development of ON in rabbits.Methods. Thirty-nine rabbits were injected once intramuscularly with either 25 mg/kg prednisolone sodium succinate (PSL; 13 rabbits), 20 mg/kg methylprednisolone acetate (MPSL; 13 rabbits) or 20 mg/kg triamcinolone acetonide (TR; 13 rabbits). Four weeks after corticosteroid injection, the bilateral femora and humeri were examined histopathologically for the presence of ON. Haematological examinations were performed before and after corticosteroid injection.Results. MPSL treatment (17/26 proximal femora, 65%) significantly increased ON incidence in the proximal femora compared with the levels seen after TR (4/26, 15%) or PSL (3/26, 12%) treatment (P