Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction.
Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction.
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DOI：
10.2174/187152710793361513
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发表时间：
2010-11
期刊：
影响因子：
--
通讯作者：
Martin B
中科院分区：
文献类型：
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作者：
Cong WN;Golden E;Pantaleo N;White CM;Maudsley S;Martin B
神经内分泌激素ghrelin是一种辛酰化的28个残基的肽，发挥许多生理功能。Ghrelin主要通过高度保守的G蛋白偶联受体（称为生长激素促分泌素受体亚型1a（GHS-R1a））对机体发挥作用。Ghrelin和GSH-R1a在外周和中枢组织/器官中广泛表达，Ghrelin信号在维持能量平衡和神经元健康方面起着关键作用。生长素释放肽及其受体的多种促食欲作用已被非常详细地研究，并且GHS-R1a介导的生长素释放肽信号传导长期以来一直是治疗代谢紊乱（如肥胖）的有希望的靶点。除了其良好的代谢作用外，还有越来越多的证据表明ghrelin介导的GHS-R1a信号传导对大脑产生神经保护作用。在这篇综述中，我们将总结一些ghrelin介导的GSH-R1a信号对外周能量平衡和认知功能的影响。我们还将讨论GSH-R1a介导的ghrelin信号在治疗复杂神经内分泌疾病中的潜在药理作用。
The neuroendocrine hormone ghrelin is an octanoylated 28-residue peptide that exerts numerous physiological functions. Ghrelin exerts its effects on the body mainly through a highly conserved G protein-coupled receptor known as the growth hormone secretagagogue receptor subtype 1a (GHS-R1a). Ghrelin and GSH-R1a are widely expressed in both peripheral and central tissues/organs, and ghrelin signaling plays a critical role in maintaining energy balance and neuronal health. The multiple orexigenic effects of ghrelin and its receptor have been studied in great detail, and GHS-R1a-mediated ghrelin signaling has long been a promising target for the treatment of metabolic disorders, such as obesity. In addition to its well-characterized metabolic effects, there is also mounting evidence that ghrelin-mediated GHS-R1a signaling exerts neuroprotective effects on the brain. In this review, we will summarize some of the effects of ghrelin-mediated GSH-R1a signaling on peripheral energy balance and cognitive function. We will also discuss the potential pharmacotherapeutic role of GSH-R1a-mediated ghrelin signaling for the treatment of complex neuroendocrine disorders.