Platelet motion near a vessel wall or thrombus surface in two-dimensional whole blood simulations.
Platelet motion near a vessel wall or thrombus surface in two-dimensional whole blood simulations.
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DOI：
10.1016/j.bpj.2013.01.061
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发表时间：
2013-04
影响因子：
3.4
通讯作者：
T. Skorczewski;L. Erickson;A. Fogelson
中科院分区：
文献类型：
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作者：
T. Skorczewski;L. Erickson;A. Fogelson
采用二维格子Boltzmann浸没边界方法进行了计算模拟，以研究血小板在血管壁附近和血管内血栓附近的运动。生理体积分数的变形红细胞和刚性血小板大小的椭圆形颗粒进行了研究小动脉流动条件下。在血管壁附近的红细胞耗尽区，血小板的翻滚受到附近红细胞的强烈影响。血栓附近红细胞耗尽区的厚度大大减少，该区域的血小板被推到靠近血栓表面的距离，以促进它们与血栓的凝聚。血小板-血栓接触的距离、性质和持续时间受到血栓孔隙率的影响。必须考虑红细胞运动和血栓孔隙度对血小板-血栓相遇的强烈影响，以了解血小板附着于生长血栓的动力学。
Computational simulations using a two-dimensional lattice-Boltzmann immersed boundary method were conducted to investigate the motion of platelets near a vessel wall and close to an intravascular thrombus. Physiological volume fractions of deformable red blood cells and rigid platelet-size elliptic particles were studied under arteriolar flow conditions. Tumbling of platelets in the red-blood-cell depleted zone near the vessel walls was strongly influenced by nearby red blood cells. The thickness of the red-blood-cell depleted zone was greatly reduced near a thrombus, and platelets in this zone were pushed close to the surface of the thrombus to distances that would facilitate their cohesion to it. The distance, nature, and duration of close platelet-thrombus encounters were influenced by the porosity of the thrombus. The strong influence on platelet-thrombus encounters of red-blood-cell motion and thrombus porosity must be taken into account to understand the dynamics of platelet attachment to a growing thrombus.