Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
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阿尔茨海默病丁酰胆碱酯酶基因及其附近 3 号染色体标记的分析。
DOI：
10.1093/hmg/7.5.933
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发表时间：
1998
影响因子：
3.5
通讯作者：
StGeorge-Hyslop,P
中科院分区：
文献类型：
--
作者：
Brindle,N;Song,Y;Rogaeva,E;Premkumar,S;Levesque,G;Yu,G;Ikeda,M;Nishimura,M;Paterson,A;Sorbi,S;Duara,R;Farrer,L;StGeorge-Hyslop,P
最近有报道，在载脂蛋白E基因ε4等位基因携带者中，丁酰胆碱酯酶K变异体与阿尔茨海默病有关。我们在大量的散发性和家族性AD病例中重新检测了BCHE-K等位基因的频率，我们还检测了BCHE附近3号染色体上三个遗传标记的分离情况。我们的数据既不支持BCHE-K与散发性或家族性AD的关联，也不表明3号染色体附近存在另一个基因作为家族性AD的共同原因。
The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of theBCHE-Kallele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 nearBCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.