Structure-activity relationships in the induction of hepatic drug metabolism by azo compounds.
Structure-activity relationships in the induction of hepatic drug metabolism by azo compounds.
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偶氮化合物诱导肝脏药物代谢的构效关系。
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Tokuji Suzuki
中科院分区：
文献类型：
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作者：
Shoichi Fujita;Masato Suzuki;Tokuji Suzuki
具有1-苯基偶氮-2-萘酚或1-苯基偶氮-2-萘胺部分的亲脂偶氮化合物诱导细胞色素P-448和相关的单加氧酶活性，UDP-葡萄糖醛酸转移酶对对硝基苯酚的活性，谷胱甘肽-S-转移酶对1-氯-2，4-二硝基苯的活性，醛脱氢酶和甲萘醌还原酶活性。偶氮染料的这种诱导模式与3-甲基胆蒽非常相似。测试的亲水性偶氮化合物和测试的其它亲脂性偶氮化合物（包括4-苯基偶氮-1-萘酚）均不诱导这些活性。有人建议，通过酚羟基和偶氮之间的氢键作用，形成第三个六元环稠合到萘的菲样安排是需要的诱导。
Lipophilic azo compounds possessing 1-phenylazo-2-naphthol or 1-phenylazo-2-naphthylamine moieties induced cytochrome P-448 and related mono-oxygenase activities, UDP-glucuronyltransferase activity towards p-nitrophenol, glutathione-S-transferase activity towards 1-chloro-2,4-dinitrobenzene, aldehyde dehydrogenase, and menadione reductase activities. This pattern of induction by azo dyes is very similar to that by 3-methylcholanthrene. None of the hydrophilic azo compounds tested and none of the other lipophilic azo compounds tested including 4-phenylazo-1-naphthol induced these activities. It is suggested that the formation of a third six-membered ring fused to naphthalene in a phenanthrene-like arrangement by hydrogen bonding between the phenolic hydroxyl and azo nitrogen is required for induction.
苏丹Ⅲ对药物代谢酶的影响。
影响因子：
5.1
作者：
Fujita,S;Peisach,J;Ohkawa,H;Yoshida,Y;Adachi,S;Uesugi,T;Suzuki,M;Suzuki,T
通讯作者：
Suzuki,T