Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis.
Low cefepime concentrations during high blood and dialysate flow continuous venovenous hemodialysis.
复制标题
高血流和透析液流量连续静脉-静脉血液透析期间头孢吡肟浓度低。
DOI：
10.1128/aac.05987-11
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发表时间：
2012
影响因子：
4.9
通讯作者：
Berns,Jeffrey
中科院分区：
文献类型：
--
作者：
Wilson,FPerry;Bachhuber,MarcusA;Caroff,Daniel;Adler,Rebecca;Fish,Douglas;Berns,Jeffrey
高血流量（Qb; 300 ml/min）、高透析液流量（Qd; 3 L/h）连续性静脉-静脉血液透析（CVVHD）期间头孢吡肟的剂量尚未确定。6例接受CVVHD的患者在给药后0.5、1、2、6和12 h测量了血清和流出液头孢吡肟浓度。3例患者的头孢吡肟浓度低于铜绿假单胞菌的MIC。每12小时2，000 mg或每8小时1，000 mg的剂量可增加治疗浓度下的时间。
Dosing of cefepime during high blood flow (Qb; 300 ml/min), high dialysate flow (Qd; 3 liter/h) continuous venovenous hemodialysis (CVVHD) is undefined. Six patients on CVVHD had serum and effluent cefepime concentrations measured at 0.5, 1, 2, 6, and 12 h after dosing. Three patients had cefepime concentrations less than the MIC for Pseudomonas aeruginosa. A dose of 2,000 mg every 12 h or 1,000 mg every 8 h may increase time at a therapeutic concentration.