PROGNOSTIC-SIGNIFICANCE OF THE EVALUATION OF BRONCHOALVEOLAR LAVAGE CELL-POPULATIONS IN PATIENTS WITH HIV-1 INFECTION AND PULMONARY INVOLVEMENT
PROGNOSTIC-SIGNIFICANCE OF THE EVALUATION OF BRONCHOALVEOLAR LAVAGE CELL-POPULATIONS IN PATIENTS WITH HIV-1 INFECTION AND PULMONARY INVOLVEMENT
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DOI：
10.1378/chest.100.6.1601
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发表时间：
1991-12-01
期刊：
影响因子：
9.6
通讯作者：
SEMENZATO, G
中科院分区：
文献类型：
--
作者：
AGOSTINI, C;ZAMBELLO, R;SEMENZATO, G
为了研究BAL细胞群的形态学和免疫学评价在确定死亡风险中的预后效用，我们分析了从115例HIV-1感染患者中获得的BAL数据。73例OI患者中发生了40例致死性结局。与存活患者相比，死亡的OI患者的中性粒细胞显著增加。此外，在01的HIV-1感染患者中发现BAL嗜中性粒细胞与高死亡风险密切相关。42例无OI者中死亡11例。与存活者相比，具有致死性结局的无OI患者的CD 3+和CD 8 + BAL淋巴细胞增加。淋巴细胞性肺泡炎的存在与死亡率的显著增加相关。综上所述，我们的数据表明，BAL细胞群的评价可能有助于预测HIV-1感染患者的致死性结局风险。
To investigate the prognostic utility of the morphologic and immunologic evaluation of BAL cell populations in determining mortality risk, we analyzed BAL data obtained from 115 patients infected with HIV-1. Forty fatal outcomes occurred within 73 patients with OI. The OI patients who died showed a significant increase in neutrophils with respect to surviving patients. Furthermore, the finding of a BAL neutrophilia in HIV-1-infected patients with 01 strongly correlated with a high risk of death. Among 42 cases without OI, 11 patients died. Patients without OI who had a fatal outcome showed an increase in CD3+ and CD8+ BAL lymphocytes with respect to the survivors. The presence of a lymphocytic alveolitis was associated with a significant increase in the mortality rate. Taken together our data suggest that the evaluation of the BAL cell populations might be useful in predicting the risk of fatal outcome in patients with HIV-1 infection.